endcopdnow.bsky.social
Researcher on lung regeneration, hope for lung disease. Let's STOP 'maintaining' diseases and start working toward curing them. Sorry but no DMs please.
🌈💙💙💙🏳️🌈🇺🇦
#ClimateAction, #universalhealthcare, #vaccines, #GunControl, #Prochoice
1,479 posts
4,467 followers
6,756 following
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Shhh. Let's keep that between us non-trumplicans.
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Okay I must have been tired. That was supposed to be so now we are back to asking the question 'did he really win the election?'
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bsky.app/profile/af68...
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This will let you know which Congress people really care about our democracy.
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This website shows how each congress member feels on the impeachment of Donald Trump. Get ready to vote them out if they do not support it.
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Will no longer donate to Democrats who rollover to Republicans destroying our democracy. This is a better place.
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anti-fibrotic strategies. We also discuss the design of biomarkers to investigate fibrosis pathophysiology, track fibrosis progression, systemic damage, and fibrosis resolution.
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persistently fibrotic cell niche that compromises organic function and ultimately drives systemic disease. Here, we review our current understanding of the structure of the ECM, the mechanisms behind organ-specific fibrosis, resolution, healing and regeneration, as well as the development of...
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This study provides a new framework for understanding how nano-drugs behave in complex biological environments by integrating the concept of "structural pharmaceutics" with 3D organ-level mapping.
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diseased tracheas and quantitatively assess effects in a noninvasive yet highly detailed manner. These techniques helped confirm the structural repair and anti-inflammatory efficacy of DEX@GCC at both tissue and cellular levels.
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Mice treated with DEX@GCC recovered body weight more rapidly, exhibited improved lung function, and showed significantly reduced inflammatory markers in bronchoalveolar lavage fluid compared to free DEX (higher dose) or model groups.
Virtual endoscopic imaging allowed them to "see" the inside of
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When loaded with dexamethasone (DEX), a commonly used corticosteroid, the GCC system not only prolonged drug retention in vivo but also displayed a controlled-release profile.
The formulation also showed strong anti-inflammatory effects in a lipopolysaccharide-induced bronchitis mouse model.
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essential for lung development, maintenance and repair, especially under physiological injury. Our results suggest that alveolar organoids may be a model for epithelial cell regeneration and the inflammatory response in lung tissue.
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to promote functional lung repair. Kevin Seitz, MD, MSc, assistant professor of Medicine, will design and lead a multicenter, randomized, pragmatic clinical trial involving more than 4,500 critically ill patients on mechanical ventilation in the intensive care unit.
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improving the translation of preclinical findings to clinical applications.
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-related diseases and facilitating the development of targeted therapeutic strategies. Its ability to simulate majority of the spectrum for smoke exposure conditions and its incorporation of mechanical forces make it a reliable model for advancing our understanding of respiratory diseases and...
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to cigarette smoke extract, emphasizing the necessity of using whole smoke for realistic toxicity assessments. The CFAX12 platform, therefore, proves to be an essential tool for preclinical research, enabling detailed exploration of the cellular and molecular mechanisms underlying cigarette smoke
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