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evanirvingpease.bsky.social
Assistant Professor at the Globe Institute, UCPH aDNA | Complex Traits | Selection | 🇦🇺🇬🇧💀🧬
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Prolific Poster
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Thank you!
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Congratulations on the award! Commiserations on the current state of US science funding 😔
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Paper is published open access here www.cell.com/cell/fulltex...
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11/ Here’s the wild part: A mutation that damages an immune gene sounds bad. But in the context of evolving human societies, it might’ve been a life-saving adaptation.
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23/ In summary: ✅ CCR5delta32 arose once, >6,700 years ago ✅ It spread via Bronze Age demographic expansions ✅ Underwent strong positive selection ✅ Is now a globally relevant variant in medicine All from an ancient immunogenetic adaptation.