fletcherlabucb.bsky.social
Bioengineering, Biophysics, Computational Biology and Molecular and Cell Biology. Account run by students/post-docs.
Lab website: https://fletchlab.berkeley.edu/
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Thanks to our collaborators: @gatesfoundation.bsky.social, @isaacbogoch.bsky.social, Spotlab, GH Labs, ISM, CERMEL, UHN, among others.
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This supports the idea that target cell's biophysical properties regulate the decision to trogocytose instead of phagocytose, as Caitlin Cornell @fletcherlabucb.bsky.social proposed in their recent preprint: doi.org/10.1101/2024.12.02.626490
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Using fluorescence anisotropy and theoretical modeling, we can now quantify how floppy or rigid molecules are when they're attached to surfaces. We tested it on DNA and red blood cell surface molecules! #biophysics #microscopy #DNA #cellbiology #anisotropy
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At the beginning of the video, the macrophage is trogocytosing a giant unilamellar vesicle at low tension (0.27 mN/m). Pipette suction is applied and tension is increased to 3.68 mN/m and the macrophage begins to engulf the GUV. #macrophages #trogocytosis #GUV #biophysics