gallardo-seq.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Who are the functionaries carrying out the destruction of the NIH? The Gang of Four: Memoli, McElroy, Schnabel, Bhattacharya. There are others, but these men play major day-to-day roles, they are the implementers, the enforcers, the true believers. www.thenation.com/article/poli...

submitted 14 days ago • 7 comments

Check out our recently published paper about identifying RNA modifications from raw Nanopore data: www.nature.com/articles/s42... Congrats to Jannes, Manja and all the co-authors!

submitted 23 days ago • 0 comments

Couldn’t wait to share - SQUARNA 2.0 is here, with greatly improved performance in single-sequence RNA secondary structure prediction! github.com/febos/SQUARNA Updated preprint is coming soon :) #SQUARNA #RNA #2D #Structure #Prediction #Bioinformatics #Research #Pseudoknot

submitted 24 days ago • 0 comments

Important 🧵 if your research depends on genome assemblies from long (PacBio / ONT) reads. As @merenbey.bsky.social says, these may not be the genomes you are looking for. TLDR: the assemblers are wrong and predict too many small circular contigs.

submitted 23 days ago • 1 comment

🧬 Happy National DNA Day! 🧬 Today we celebrate the completion of the human genome project (2003) and discovery of the double helix (1953). From genome editing to RNA therapeutics, research into nucleic acids continues to drive scientific breakthroughs #NationalDNADay #NucleicAcids #DNAday2025

submitted 27 days ago • 1 comment

The Palantirs were originally made so that the Men of the West could communicate. But then they were taken over by the Enemy to spread corruption, sow fear, and spread disinformation to destroy the world of Men. Kudos to Peter Thiel for choosing the most accurate name for his company.

submitted 29 days ago • 1 comment

BREAKING: On Friday, the federal government issued new demands of Harvard University. The university's lawyers just responded: back off.

submitted 37 days ago • 118 comments

This is not a drill…

submitted 42 days ago • 0 comments

Leavitt confirmed that the WH is working on deporting US citizens to El Salvador

submitted 43 days ago • 2177 comments

longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/lon...

submitted 58 days ago • 3 comments

When the occasion demands the Machiavellianism of a McConnell but all you have to offer is the ‘make nice’ of a Schumer Like I’ve said before… Disney characters who don’t know they’re trapped in a Tarantino film

submitted 69 days ago • 2 comments

This is the formal end of the Democratic Party on the national stage. There is no constituency for an opposition party that doesn’t oppose.

submitted 69 days ago • 9 comments

The institutional Democratic Party is guided by an almost pathological level of conflict avoidance in almost every direction. “What can we do to make the least number of people mad?” is just a bankrupt way to operate.

submitted 69 days ago • 3617 comments

Where is the lie? theonion.com/democrats-si...

submitted 69 days ago • 2 comments

“You aren’t kissing Dear Leader’s ass enough” is a helluva foreign policy.

submitted 82 days ago • 1 comment

Read every word of this article to see what the Trump folks are doing to the good civil servants at NIH -- and to the important work that protects all of our health. www.theatlantic.com/health/archi...

submitted 83 days ago • 8 comments

Five alarm fire. www.politico.com/news/2025/02...

submitted 84 days ago • 738 comments

RNA xkcd.com/3056

submitted 84 days ago • 161 comments

Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT apple.news/APlQhGHRrSfy...

submitted 91 days ago • 0 comments

You excited for March 7th?! Get in contact with local organizers at your state capitols! airtable.com/app4h5wUssMG...

submitted 94 days ago • 1 comment

Sickening how the mainstream media and our elected representatives have been so passive about this constitutional crisis.

submitted 107 days ago • 0 comments

and unconstitutional…

submitted 108 days ago • 0 comments

Dems must go on the offensive. Our country’s safety is at risk

submitted 111 days ago • 2 comments

Ah. Clearly DEI mandates led to the hiring of invisible people.

submitted 111 days ago • 8 comments

how it feels to be working on RPPRs right now.

submitted 119 days ago • 0 comments

Study Sections (and Advisory Councils) scheduled between now and Feb 2nd Extremely alarming nonetheless, but let's make sure people have accurate info.

submitted 119 days ago • 2 comments

H/t to Nava for spotting this & posting to ASeq discord First question posted to @nanopore CEO Gordon Sanghera at #JPM25 had 2 parts: 1. Do they have long read technology? 2. Do they see value in long reads?

submitted 127 days ago • 4 comments

🤯

submitted 152 days ago • 0 comments

Hi Bluesky, just in time for the holidays I am excited to share the latest pre-print from my group! We solved the 3D structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 &link below – please also check out the full video! #RNA #RNAbiology #RNASky #lovevirology

submitted 152 days ago • 8 comments

My replies are perpetually full of anti-vaxxers these days telling me about polio vaccines. Not shockingly, most of what they are saying is wrong. Luckily, I trained with Vincent Racaniello & he taught me a few things about poliovirus. So let’s discuss the king of the Picornaviridae👇🏻

submitted 154 days ago • 36 comments

Just had my first experience with CycloneSEQ data and shared my findings in this blog post: rrwick.github.io/2024/12/17/c... How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!

submitted 156 days ago • 0 comments

Research thrives on innovation and the diversity of ideas, yet our funding system often penalizes both. In our new study published in PNAS, we explore the hidden costs of competition in allocating scarce research funds. (1/10) www.pnas.org/doi/10.1073/...

submitted 170 days ago • 4 comments

Reply below if you want to be included in the #nanopore starter pack! go.bsky.app/VCoo6T

submitted 173 days ago • 14 comments

TechBio Transformers (founded by @dr-alphalyrae.bsky.social) is a growing global community of folks who want to (+)ly impact the field of technology & biology, while also intentionally building healthy dialogue and community Follow along, & even consider joining the group! bsky.app/starter-pack...

submitted 177 days ago • 2 comments

It’s great to see this thorough validation of DMS chemical probing of RNA structure. I think the DMS reactivity “continuum” issue and the interplay with sequence context issue can be addressed with new ML models combined with 4-base sensitive DMS.

submitted 177 days ago • 1 comment

RNAkinet identifies nascent RNA by predicting 5EU metabolically labeled #RNA from raw #nanopore electrical signal. Should allow association of RNA metabolism dynamics with isoform usage, poly(A) tails and native RNA mods. academic.oup.com/nargab/artic...

submitted 179 days ago • 3 comments

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

submitted 178 days ago • 6 comments

Welcome!!

submitted 180 days ago • 0 comments