gottschalklab.bsky.social
Systems Immunology and Macrophage Signaling
Assistant Professor at U Pitt
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We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...