Profile avatar
jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
792 posts 1,412 followers 2,144 following
Regular Contributor
Active Commenter
Posts 23 Comments 26

🧬 What if your blood cells remembered how their ancestors divided? Our new preprint (www.biorxiv.org/content/10.1...) explores clonal memory in human blood stem cells — and how it breaks down in leukaemia. 📄 "Clonal memory of cell division..."

submitted 3 days ago • 1 comment

New preprint from the lab! Clonal memory in human hematopoietic stem cells and acute myeloid leukemia. Fantastic work led by @alessandrodonada.bsky.social. Worth reading the explanation by alessandro of the results in his thread. Thanks to everybody involved! Happy to get feedback from you all.

submitted 2 days ago • 1 comment

Does anyone have experience or know whether it is feasible (as suggested in the linked paper) to get effectively full transcript coverage up to 10kb away from the TSS of mRNA molecules in 10x single cell data?! pmc.ncbi.nlm.nih.gov/articles/PMC...

submitted 1 day ago • 1 comment

www.science.org/doi/10.1126/...

submitted 1 day ago • 0 comments

www.nature.com/articles/s41... GZMK is so hot right now.

submitted 4 days ago • 0 comments

Nature has posted graphic images of early Denisovans and they were jacked and look sorta like Mickey Rourke.

submitted 9 days ago • 1 comment

www.science.org/doi/10.1126/...

submitted 15 days ago • 0 comments

www.biorxiv.org/content/10.1...

submitted 18 days ago • 0 comments

Check out our new paper! “Dynamic Control of Argonautes by a Rapidly Evolving Immunological Switch” @currentbiology.bsky.social Congrats @ethanewe.bsky.social🥂🥂🥂 kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

submitted 19 days ago • 0 comments

Seems like these folks are arguing that we don’t need multiple testing corrections in big omics studies as long as there’s extra experiments. Whatcha think? www.nature.com/articles/s41...

submitted 24 days ago • 6 comments

Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells @cp-cellrepmed.bsky.social @dimiccolab.bsky.social www.cell.com/cell-reports...

submitted 24 days ago • 0 comments

Am I missing something here or does this paper report finding large clonal T cell populations shared across diverse tissues in humans using random T cells and sparse sampling (10x)? That surprises the hell out of me... CMV-reactive? www.nature.com/articles/s41...

submitted 30 days ago • 2 comments

Huh! www.science.org/doi/10.1126/...

submitted 37 days ago • 0 comments

'This commercialisation has created a system where behaviours and actions that benefit publishing are rewarded, whether or not they benefit science—and in some cases even if they are to its detriment.' onlinelibrary.wiley.com/doi/full/10....

submitted 41 days ago • 0 comments

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

submitted 42 days ago • 1 comment

The cell number bragging in single cell is out of control! I call upon all those who do FACS to brag about the number of single cells in your datasets so that we can put an end to this nonsense 😂

submitted 45 days ago • 1 comment

I’m thinking about adding a slide to my talks about “markers of unknown meaning” aka “MOUM”

submitted 46 days ago • 1 comment

Every morning this guy crawls under my breakfast chair and refuses to leave… he bites my feet and the chair until I play frisbee with him

submitted 47 days ago • 1 comment

This platform from Element biosciences looks really cool for studying cells in culture spatially - www.biorxiv.org/content/10.1...

submitted 48 days ago • 0 comments

It’s about demonstrating that you are a person who is aware you live in a society and want to be kind to others vs a person who only fixates on their own needs and is oblivious to the feelings of others… edition.cnn.com/2024/05/09/o...

submitted 48 days ago • 0 comments

First paper out from lab run entirely by bears: www.cell.com/cell/fulltex...

submitted 50 days ago • 0 comments

www.science.org/doi/10.1126/...

submitted 51 days ago • 0 comments

We found that cells use emergent collective memory—arising from simple chemical reactions—to outperform physical limits of detecting chemical gradients. Curious how? 1/n 8 min talk: www.youtube.com/watch?v=A7XH... bioRxiv: www.biorxiv.org/content/10.1... #biophysics #cellbiology

submitted 54 days ago • 1 comment