jkmcbee.bsky.social
LCMS weirdo. Pretend expert in all things charged or separated. Biking aficionado, coffee enthusiast, destroyer of mass spectrometers.
95 posts
455 followers
939 following
Getting Started
Active Commenter
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Delaware pickleball is vicious man.
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That’s a big field.
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“The gorillas will freeze to death in the winter!”
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I feel like time of flight is a valid approach here. Maybe a bunch of trampolines for multi reflectron.
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The progress in drugs for treating cardiovascular disease over the last 5 years alone is remarkable. Drugs like Repatha and Leqvio virtually halt plaque deposition. The current guidelines for someone with CVD are to have your LDL-C below your HDL.
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Many of the original Stephen King adaptations
Firestarter
Christine
The Dead zone
And Cujo scared the bejesus out of me as a kid
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Also Prince of Darkness is pretty solid 80’s horror
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Was thinking the original Cronenberg.
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Dead Ringers?
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“It takes two to lie Marge, one to lie and one to listen!”
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Achieve mystical levels of proteome coverage!
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Putting in a vote for Orbitrap Astral Plane…
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Two fistfuls of Dollars.
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4020: the year we made contact…and charged them for it.
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I noticed the LECO patent expired last year as well…
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More likely that Thermo filed it as a “non-obvious” improvement of existing IP which is a bit of a grey area
In patents but allowable
If you look at Mobilion patents they filed something similar using a 2 dimensional traveling wave as a pre-filter on PCB boards
patents.google.com/patent/US122...
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Waters has increasingly been reliant on selling consumables and services rather than instrument sales. Their r&d spend is less than the other companies and IMO they suffer from a lack of diversification so if the LCMS business is in a lull, the whole company is hurting. It puts them in a tough spot.
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They have still been hampered by others IP. The Astral, if I recall, uses stacked ADC chips which until recently was owned by Agilent but I think the pate t recently expired. I do know the Astral uses the Acquiris 14-bit ADC in dual
Channel mode.
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The mrTOF is a LECO patent licensed by both companies. Also, the success of the Orbi has allowed Thermo to spend multitudes more than the other companies on HRMS. That combined with being part of a large diverse company gives them lots of resources to find “improved” ways to implement a technology.
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A recommend against it. I went with my kids once about 10 years ago and left
With a torn labrum in my right hip. That was my first real reality check that I was getting old.
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My alma mater as well. I miss the campus and Seattle in the spring very much.
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You forgot my personal favorite of his: Real Genius.
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It’s like a Cybertruck for your feet!
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DDM was critical for determining the first GPCR crystal structure, Rhodopsin. It’s a great mild detergent.
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Man and they were so close to finishing the game.
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I can also highly recommend Herschel’s Deli. Get the Reuben.
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I mean the lord of the rings movies are pretty close to 4 years long…
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Tuning a quadrupole with dials.
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Never trust the trunk vaccine….
This guy was openly advertising on Facebook and I had to privately advise friends not to take it. I eventually handed everything I had over to the AG’s office.
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I can top that. I knew a guy that got busted handing out bogus Covid shots at $400 a pop. I turned down the offer.
www.justice.gov/usao-wdwa/pr...
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Live dangerously, in 2025 have two!
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Late nite tamales are the best tamales.
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I believe the Romans used to pay soldier wages with followers.
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My mom when I did something disappointing….
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Ahh, I can still smell the benzene!
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This sounds like a nice new hobby for someone.
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The same can apply for quads, collision cells etc. we had a project years ago where a customer paid extra for us to find the “hottest” instruments. And indeed we found several that were 5x more sensitive than spec. It was a massive effort and the company went out of business anyway…
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Instruments across the same model can indeed run hot and cold. Resolution spec on some TOF systems is set by taking 10 or so units off the production line and setting the spec two std deviations below the average. That way you can guarantee 95% of systems will pass spec in the field.
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I was processing MS data.
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We did a POC using LC-SLIM-TOF of an untargeted/targeted assay for drugs of abuse in urine which substantially
Sped up the backend sample analysis speed. This is probably where the tech will end up. Otherwise the Cobas is a marginal improvement over products that ultimately failed
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This has been tried before. Both Sciex/BD and Thermo have released the Topaz and Cascadia. Both times the limitation has been the use of the QQQ which requires Roche to design and validate menu choices for analytes which is what doomed previous attempts. The complexity and costs are also limiting.
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Ooh the dream sequence from that movie still gives me chills.