jnpruneda.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!

submitted 6 hours ago • 1 comment

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social www.biorxiv.org/content/10.1...

submitted 3 days ago • 0 comments

Excited to share that my work in the @aaronwhiteley.bsky.social lab describing chaperone-mediated phage sensing by a bacterial NLR-related protein is out in @plosbiology.org!

submitted 3 days ago • 1 comment

Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.

submitted 4 days ago • 0 comments

our lab is blessed to have 3 new postdoctoral fellow positions. we would welcome scientists interested in...

submitted 5 days ago • 1 comment

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

submitted 8 days ago • 3 comments

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

submitted 9 days ago • 12 comments

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

submitted 10 days ago • 0 comments

April 20-24, 2026 Save the date!

submitted 11 days ago • 0 comments

Our latest preprint on peroxisomal fatty-acid transport is live!! @ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF

submitted 11 days ago • 1 comment

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s! @natsmb.nature.com 1/7 www.nature.com/articles/s41...

submitted 12 days ago • 4 comments

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

submitted 15 days ago • 0 comments

If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬 Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support! doi.org/10.1126/scia...

submitted 16 days ago • 1 comment

Out in @pnas.org today Showcasing the power of NMR! NMR and enzyme kinetics show USP7 enzyme transiently sampling its low-populated active state, and its hyperactive disease variant enhancing these dynamics www.pnas.org/doi/10.1073/... Stellar work by students Gabrielle Valles and Emilie Korchak

submitted 17 days ago • 0 comments

Very happy to share two back-to-back preprints of my postdoc work on bacterial NEL E3 ligases from my time in @katrinrittinger.bsky.social lab at @crick.ac.uk in collaboration with the ChemBio team at GSK (1/4)

submitted 17 days ago • 1 comment

Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work! @ohsunews.bsky.social @ohsummi.bsky.social www.nature.com/articles/s43...

submitted 19 days ago • 0 comments

Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!

submitted 21 days ago • 0 comments

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...

submitted 21 days ago • 4 comments

How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!

submitted 25 days ago • 0 comments

Great to see this out. A story that spanned continents, cities and budget codes… www.nature.com/articles/s41... Big thanks to all the teams involved! @clausenlab.bsky.social @e3chembio.bsky.social

submitted 25 days ago • 3 comments

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

submitted 31 days ago • 1 comment

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

submitted 33 days ago • 3 comments

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

submitted 34 days ago • 2 comments

Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...

submitted 38 days ago • 0 comments

How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n

submitted 39 days ago • 2 comments