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joris-vd-haar.bsky.social
Clinician-scientist / precision medicine / cancer immunology / bioinformatics / MD, PhD @Netherlands Cancer Institute / ESMO precision medicine working group Trying to have fun discovering stuff to help patients. Opinions are my own.
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Important work towards one of the holy grails in cancer immunotherapy: understanding/predicting/designing TCR specificities

Read our ESMO recommendations on MTBs for precision medicine here: www.sciencedirect.com/science/arti...

Highly recommended!

We are hiring! www.nki.nl/careers-stud... @nkinl.bsky.social

🤙🤙🤙 Precision oncology starter package

We live in exciting times www.nejm.org/doi/full/10....

Cool concept

Imagine how many black and white pictures could have been published in full color

Magnificent work from Monika Wolkers and team : γδ T cells are the prime anti-tumoral T cells in pediatric neuroblastoma Another case where γδ T cells are the central effectors of anticancer immunity. www.biorxiv.org/content/10.1... @forum-gd.bsky.social

Big if true: do cancer cells transfer mutated mitochondria into tumor infiltrating lymphocytes to impair their function? mtDNA is challenging to work with, so looking forward to see this finding confirmed. But cool concept and big congrats to the authors! www.nature.com/articles/s41...

1/2 Puzzling result from the DRUP study: the more mutations driving proliferation in a tumor, the less effect of targeting only one of them with specific drugs. www.esmoopen.com/article/S205...

Bizarre story. Genetic Analysis of a Sarcoma Accidentally Transplanted from a Patient to a Surgeon | New England Journal of Medicine www.nejm.org/doi/full/10....

Forget Die Hard vancomycin is a Christmas antibiotic

Awesome www.nature.com/immersive/d4...

Impressive www.science.org/content/arti...

🤩🤩🤩 www.nature.com/articles/s41...

I'm pleased to share that I will be speaking at the Clinical Cancer Genomics meeting, taking place on the 20th-21st of March 2025 in Amsterdam. Register now to join me and discuss the latest developments with leading experts in the field: www.ccg2025.eu #CCG2025

Looking forward to speaking at the Clinical Cancer Genomics conference on March 20-21, 2025 in Amsterdam. Very nice and inspiring program with many European heavyweights, inc Edwin & many others. Register via the link below!👇

Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer | New England Journal of Medicine www.nejm.org/doi/full/10....

Some cool novel concepts: Nat biotech: platelets for targeted degrader delivery www.nature.com/articles/s41... Science: T cells for targeted drug delivery www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Beautiful study by Jacco van Rheenen, Colinda Scheele & team about the impact of the menstrual cycle on neoadjuvant chemotherapy in young women with breast cancer. Cutting-edge fundamental science with direct implications for women and families @nkinl.bsky.social www.nature.com/articles/s41...

All 2024 changes in precision oncology beautifully outlined👇🚨 aacrjournals.org/cancerdiscov...

Interesting read👏👏👏 aacrjournals.org/cancerdiscov...

Any new 🦋 arrivals? go.bsky.app/xg4Y26

Any recent 🦋 arrivals?

Powerhouse 🤩

1/3 In this week’s NEJM: Andre et al report very positive results of dual ICB in MSI cancers. Logical, right? But why is this very interesting from an immunological point of view? About 75% lacks HLA class I. Likely innate immune mechanisms are centrally involved dx.doi.org/10.1158/1078...

Exciting news in cancer therapy! The order of drugs impacts the duration of treatment, toxicity, and economic cost. A necessary example of how relevant academic, self-funded trials are!! Breast #cancer #oncosky #oncsky #medsky 🧪 @natureportfolio.bsky.social www.nature.com/articles/d41...

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...