kacarlab.bsky.social
Past, Present and Future of Life
Here and Elsewhere
PI: Betül Kaçar
Account managed by lab members.
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kacarlab.org
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Prolific Poster
Conversation Starter
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By tracing 3 pivotal moments in Earth’s history—the origin of prokaryotic cells, the emergence of eukaryotic complexity and the rise of multicellularity—the report offers fresh insight into life’s origins and a bold vision for future scientific discovery. Hope you enjoy reading it! @asm.org
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Microbial life underpins all living systems and understanding its origins could help solve today’s biggest challenges. As a companion, we previously published a @annualreviews.bsky.social piece on reconstructing early microbes, providing key context & insights!
www.annualreviews.org/content/jour...
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Thanks for sharing! Proud grad student moment!
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Ferroptosis approved!!!
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To sum: At the very root of eukaryotic origins is a story of microbial stress responses!
Keywords: #iron and #homeostasis
Hope you enjoy reading it!
@uwbact.bsky.social @uwmadscience.bsky.social #UWMadisonGeoscience #NASA
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Our study challenges oxygen-centric views of eukaryotic origins.
We argue mitochondria’s role in respiration is inseparable from iron metabolism, both biochemically & geochemically, and propose ferroptosis evolved as an ancient response to iron toxicity.
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We propose that high iron levels in ancient oceans disrupted cellular systems & triggered biochemical stress, delaying the emergence of eukaryotes until iron declined. Our detailed histogram of ironstone occurrence shows that iron's decline broadly overlaps with the earliest eukaryotic microfossils!
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you bet!
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Thank you!
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💜
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3️⃣ Klos et al.: Showed that metal (specifically, Molybdenum)-pathways predate O₂! Inviting us to rethink molybdenum availability on early Earth ➡️
www.biorxiv.org/content/10.1...
#Origins #AncientLife #NitrogenCycle
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2️⃣ Sobol et al.: Demonstrated that nitrogen fixation networks co-evolved with Earth's shifting environments ➡️
www.biorxiv.org/content/10.1...