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kguynes.bsky.social

Scientist @IMBA_Vienna | PhD @ Martin-Duran Lab (QMUL) | MSc @ Partridge Lab (IHA, UCL)

5 posts 36 followers 101 following

Posts 17 Comments 2

A 🧵 to walk those interested through this paper...

submitted 12 days ago • 4 comments

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

submitted 47 days ago • 12 comments

@laghalab.bsky.social excellent talk at the RNA Biology Microsymposium today! I appreciate talks where models and the ways in which they can (and cannot) lend themselves to studying a given question are discussed!

submitted 20 days ago • 1 comment

For a new Perspective in GBE, Au et al. provide an overview on whole genome duplications in animals, arguing that they have occurred frequently across invertebrates; expanding WGD studies is thus essential for understanding metazoan evolution. 🔗 doi.org/10.1093/gbe/... #genome #duplication

submitted 20 days ago • 0 comments

Out now in @ScienceAdvances 👇 science.org/doi/10.1126/... BRAVO @tomsexton_lab and super help from @tinekelenstra.bsky.social @mitchell_lab @akispapantonis.bsky.social @molina_lab @evisoutoglou.bsky.social @NeoVirTech

submitted 165 days ago • 2 comments

Proud of you ☺️

submitted 21 days ago • 0 comments

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

submitted 24 days ago • 2 comments

Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social Very happy to see this come to fruition- Look forward to feedback from colleagues ! More 👉 www.cell.com/cell/fulltex...

submitted 35 days ago • 3 comments

Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions www.biorxiv.org/content/10.1...

submitted 34 days ago • 0 comments

FYI: New online! Computational analysis of DNA methylation from long-read sequencing

submitted 40 days ago • 0 comments

Genomic erosion through the lens of comparative genomics https://www.biorxiv.org/content/10.1101/2025.03.28.645899v1

submitted 59 days ago • 0 comments

New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes. #TEsky biorxiv.org/content/10.110…

submitted 79 days ago • 4 comments

March issue: Amino acids that are more different do have lower rates of exchange over evolutionary time, and this result is general to different taxonomic groups. doi.org/10.1093/gbe/... #MolecularEvolution #AminoAcids #OpenAccess

submitted 80 days ago • 0 comments

Such incredible findings!! And so much data to continue exploring

submitted 95 days ago • 0 comments

Universal orthologs infer deep phylogenies and improve genome quality assessments https://www.biorxiv.org/content/10.1101/2025.02.17.638702v1

submitted 95 days ago • 0 comments

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

submitted 110 days ago • 3 comments

SY-Stem 2025 Symposium: Registration deadline on February 15th! SY-Stem - a symposium focusing on the next generation of stem cell researchers - is organized by IMBA and @impvienna.bsky.social. Register online: bit.ly/4jekaDg Check out the program: bit.ly/4jDioM6

submitted 112 days ago • 0 comments