kjantarug.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🚨 preprint 2️⃣ this month: our (purely experimental🧪) venture into #ChemBio We prouldy present: ADD-tagging of proteins (or "ADDing") —a super convenient enzymatic technique to install click chemistry handles on proteins. Led by superstar @wahyuwidodo.bsky.social www.biorxiv.org/content/10.1... A 🧵👇🏽

submitted 4 days ago • 4 comments

We’re hiring. Postdoctoral and PhD positions available in Medicinal Radiochemistry. Must have high level of skills and experience in synthetic chemistry, with knowledge of radiochemistry, cellular studies, in vivo imaging desirable. @erc.europa.eu @snsf-ch.bsky.social @chemuzhch.bsky.social

submitted 14 days ago • 0 comments

We’re excited to share new work on the continuous in vivo evolution of gene libraries towards arbitrary functions. Led by superstar Olek Pisera, our experiments show that gene evolution is highly versatile... www.biorxiv.org/content/10.1...

submitted 18 days ago • 1 comment

Lead author @ssmelyansky.bsky.social spearheaded a strategy to label a single sulfur-containing glycan called ManLAM on the cell envelope of the bacteria that cause #TB. news.mit.edu/2025/new-mol... or here: www.pnas.org/doi/10.1073/... 🧪 #glycotime @mitchemistry.bsky.social

submitted 19 days ago • 3 comments

A quantitative yeast-surface display and FACS approach generates fully human conformational antibodies against amyloid aggregates without the need for immunization www.nature.com/articles/s41...

submitted 19 days ago • 0 comments

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

submitted 23 days ago • 6 comments

📣 #Call for #Postdoc.Mobility. Expand your #research experience with a stay abroad. If you would like to find out more about this call, take part in our online information event on 12 May 2025. ➡️ buff.ly/Q2KkBWd 📆 Submission deadline: 5 August 2025

submitted 24 days ago • 0 comments

Check out the nice News and Views article about our work from lead author @sijiewang.bsky.social using phage display to find covalent inhibitors of protein-protein interactions. #ChemBio www.nature.com/articles/s41...

submitted 23 days ago • 0 comments

Happy to share the results of a fun side project in which we used the COUPY dye and mutants of HaloTag7 to show that changes in fluorescence lifetime correlate with the polarity of the protein binding pocket! chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... #FLIM #fluorescence #HaloTag

submitted 24 days ago • 0 comments

New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...

submitted 36 days ago • 1 comment

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...

submitted 35 days ago • 0 comments

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

submitted 34 days ago • 8 comments

Improving split-HaloTag through computational protein engineering: onlinelibrary.wiley.com/doi/10.1002/...

submitted 36 days ago • 0 comments

My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty

submitted 47 days ago • 1 comment

🚨Open PhD positions in chemical biology!🚨 Join us in developing chemigenetic probes for imaging and sensing. ⚗️🧫Experience in chemical synthesis and/or protein engineering? 🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment? Apply (or re-post)! jobs.uzh.ch/job-vacancie...

submitted 48 days ago • 0 comments

A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB

submitted 58 days ago • 1 comment

Exciting @biorxivpreprint.bsky.social by the group of @beattylab.bsky.social. They used meropenem-based ABPP probes to show that β-lactams demonstrate a large degree of polypharmacology in M. tuberculosis by targeting 30 different proteins. www.biorxiv.org/cont...

submitted 62 days ago • 0 comments

A comprehensive review on covalent chemical strategies for protein self-labeling from @kjohnsson.bsky.social's lab: HaloTag, SNAP-tag et al. www.annualreviews.org/content/jour...

submitted 65 days ago • 1 comment

🚨 PhD Opportunity! Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student! 🔬 Exciting interdisciplinary research 🤝 Engaging environment 🌱 📄 Does this sound like you, apply now! ⏳🔗 📢 Know someone? Share this! 🔄 jobs.uzh.ch/job-vacancie...

submitted 68 days ago • 1 comment

📢 #Preprint Alert: For #fluorescentfriday we report minimally-sized photoactivatable PaX dyes with red and far-red emission for #STED, #SMLM, and multiplexed #MINFLUX #SuperResolution #Microscopy! A huge thanks to the Optical #Nanoscopy team at @mpi-mr.bsky.social! 🔬 www.biorxiv.org/content/10.1...

submitted 86 days ago • 0 comments

Excited to share this collaborative work led by Guosong Hong’s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈 www.biorxiv.org/content/10.1...

submitted 86 days ago • 1 comment

Looking for a PhD candidate to join my group at the University of Zurich If you are an excellent and motivated student🧑‍🔬and want to integrate organic synthesis, photochemistry and redox chemistry in a research🧪 we want to know more about you! More info: www.stacko.group Appreciate sharing the post.

submitted 89 days ago • 1 comment

Now online at a peer-reviewed journal, Carla's careful characterization of the redox state of glutathione in the Golgi apparatus: www.sciencedirect.com/science/arti...

submitted 93 days ago • 0 comments

Exciting news from the lab! Our first preprint, “Hydrophobic Tuning with Non-Canonical Amino Acids in a Copper Metalloenzyme” is now available. In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary. 🔍: www.biorxiv.org/content/10.1...

submitted 103 days ago • 1 comment

Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!

submitted 103 days ago • 1 comment

It is official! The fourth edidtion of our winter school on "Fluorescence markers for advanced microscopy" will take place on March 15-20 2026 in Les Houches, in the french Alps. fluorescenceleshouches.wordpress.com Selection of participants will start in 2025. Signup on the website to be informed.

submitted 185 days ago • 3 comments

The 100th chemistry related starter pack added to the big list at tinyurl.com/ChemSkyStart... is "Org Chem 2"! Fantastic to see how the chemistry (and science communication) communities have embraced Bluesky! #ChemSky 🧪 If there are starter packs that I haven't added to this, please let me know!

submitted 110 days ago • 0 comments

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes. The proof-of-concept paper is on BioRxiv: https://doi.org/10.1101/2025.01.27.635008 . Great job done by @MarieAuvray4 at @mpi_nat ! Enjoy reading!

submitted 114 days ago • 0 comments

🧵Prepint alert! Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling | tinyurl.com/3n55hvsc. With Jason Vevea, Ed Chapman, and @so-lets-kilab70.bsky.social, we combined dye chemistry, HaloTag, microscopy and cell biology to make protein purification and manipulation tools.

submitted 117 days ago • 2 comments

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs. bioart.niaid.nih.gov

submitted 159 days ago • 14 comments

In part two of the story of #fluorescent #antimicrobial peptide UNR-1, we showcase its exceptional solvatochromism, enabling the analysis of perturbations in the bacterial cell envelope under physical and chemical stress by flow cytometry. #ChemBio pubs.acs.org/doi/10.1021/...

submitted 116 days ago • 0 comments

Brilliant work by Takeharu Nagai and team: Creating coveted bioluminescence colors for simultaneous multi-color bioimaging www.science.org/doi/10.1126/...

submitted 120 days ago • 0 comments

🚨 Registration is now open! 🚨 Join us for 'Seeing is believing: imaging the molecular processes of life', where cutting-edge imaging methods meet groundbreaking biological discoveries. 🌟#EESImaging 📅 8 – 11 October 2025 📜 Submit your abstract by 2 July! 👉 https://s.embl.org/ees25-09-bl

submitted 123 days ago • 0 comments

An #AI model created to design proteins simulates 500 million years of protein evolution in developing a previously unknown bright fluorescent protein. Learn more in a new Science study: https://scim.ag/40l2z3J

submitted 127 days ago • 2 comments

Digital and Tunable Genetically Encoded Tension Sensors Based on Engineered Coiled-Coils doi.org/10.1002/ange...

submitted 126 days ago • 0 comments

Continuous directed evolution of cyclic peptides in cells to inhibit protein aggregation. From Tina Wang et al. #chembio #ChemSky www.nature.com/articles/s41...

submitted 131 days ago • 0 comments

Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells pubs.acs.org/doi/10.1021/...

submitted 130 days ago • 0 comments

📣#OpenCall: Project funding The project funding scheme enables qualified researchers to independently carry out projects on topics and research objectives of their own choosing. Open to all disciplines. 📷 Submission deadline: 1 April 2025, 17:00 CEST. 📌 For more info ➡

submitted 136 days ago • 0 comments

www.nature.com/articles/s41...

submitted 135 days ago • 2 comments

A new paper from Martin Spinck, Amir Guppy, and Jason Chin reports computational tools for automated generation of chimeric orthogonal tRNAs and discovery of their cognate synthetases in E. coli #Chembio #chemsky #synbio www.nature.com/articles/s41...

submitted 152 days ago • 0 comments

Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨ pubs.acs.org/doi/10.1021/...

submitted 170 days ago • 0 comments

Curious what we do in my new lab at D-CHAB @ethzurich.bsky.social 🔬⚗️? Save the date for my inaugural lecture on April 3, 2025 and if you can’t wait to know more check out the news article and the associated video. chab.ethz.ch/en/news-and-...

submitted 170 days ago • 0 comments

Ph.D. student Dazhou Cheng developed a chemigenetic K+ indicator (HaloKBP), using an rHCaMP/HaloCaMP-type design! pubs.acs.org/doi/10.1021/...

submitted 171 days ago • 2 comments

🎉Congratulations to Luke Lavis (@rhodamine110.bsky.social), recipient of the 2025 Gregorio Weber Award for Excellence in Fluorescence Theory and Applications from ISS for his pioneering work on the design & synthesis of small-molecule fluorescent dyes.🧪

submitted 171 days ago • 4 comments

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

submitted 180 days ago • 10 comments

Interesting paper by the group of Rui Wang in Analytical Chemistry. They systematically studied several activated esters with heteroaromatics in the leaving group and show strong, tunable lysine labeling with high hydrolytic stability. #ChemBio pubs.acs.org/doi/10....

submitted 182 days ago • 0 comments

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

submitted 188 days ago • 48 comments