klab.bsky.social
Neurobiology Lab studying development, maintenance, and aging of the Enteric Nervous System.
Home of 'enfant terrible' of enteric neurobiology
https://www.enteric-neuron.com
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This opens up an entire new way for us to think about how autoimmunity impacts organ level disease...and even more...
In addition, this work is a perfect e.g. of a physician scientist collab...driven by 2 labs - us in fundamental sci and our collaborator Dr. McMahan at UTHealth at Houston (fin)
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Whats more! This interaction is functional as it impacts cellular respiration - a key metric of pathobiological changes observed in many diseases and disorders - showing for the first time that anti-mitochondrial autoAb are potentially drivers of disease. (5/n)
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Using cultured preps of ENS tissue and a cell line abundant in mitochondria, we showed that these anti-mitochondrial autoAb can penetrate live cells, traffic to mitochondria, and bind their target - almost like a guided missile. (4/n)
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We identified a subset of Scleroderma patients who have autoAb against #mitochondria & found that they have significant GI motility disorders.
On searching where mitochondria are abundant in the gut, we found that ENS and specifically mesoderm-derived neurons are enriched in mitochondria (3/n)
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Scleroderma is an #autoimmune diseases, where patients harbor diverse autoantibodies against self antigens. However the relevance of most of these #autoantibodies to disease was unknown, since these autoantibodies mostly target intracellular antigens (2/n)
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Or like running a tailor shop in a mall
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Shhhh...you are upsetting the folks who believe AI is the present and the future
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Disagree, look closely...in these times, they are giving free hugs
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Such a sad and shocking news!!
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Better yet, I can have any icecream i want with this app
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Problem I think isn't that institutions don't notice it, but that there is still a lot of inertia that restricts them from committing to a new order of business that's a prerequisite for a full throated affirmation of the abundance agenda
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A Nobel laureate in Medicine I met recently was one of the most 'disinterested in science' person I have ever met
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One of the very few reporters who has doggedly followed the measles story with hard data
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That epiphany came while listening to a talk at a conference I assume?
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Who knew Germ Theory was gonna go the way of the moon landing, the round earth, and other "fallen from grace" facts
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The classic "House of Cards" problem
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I knew you would be the first to comment
We live in times where farce has a good chance of becoming reality
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Thats also what is wrong about their whole issue with ASD. To fixate ONLY on exposome transfers the onus of their disease to their parents.
It is almost like a religious mentality where your pain is a natural consequence of your own (and your parents') ill actions
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Got time in your busy schedule to meet?
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Never aggravate a creative mind with stockpiles of chocolate icecream
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1. Take the said dogpoop and burn it on their doorstep
2. Take a diaper, put chocolate icecream in it and leave it at their doorstep. Add red color for better effect
3. Put up a yard sign with the words "this house starts the next pandemic" with the sign pointing at their house
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Yes, there is no complete paper. It is a mirage as new data always brings new questions
Horizons remain horizons...how many miles you travel towards it doesn't bring the horizon any closer
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Question is whether good editors are rewarded and bad editors are disciplined in the system. Same goes for good and bad reviewers
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There is no panacea and I am sure there won't be. But urgent reforms are needed and the only way forth is to experiment in multiple ways of reforms. Elife is but one such model and I am hopeful that other journals will find their own impetus to reform.
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The idea is not to overrule revs, but of defining boundaries & looking at excesses. Often the editors don't touch baseless statements & egregious requests from reviewers for the risk of overruling reviewers. I quite like the @elife.bsky.social model in this regard as a possible solution
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So if that's the editors response, why do we need editors?
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This should be standard policy, not policy during crises. Editors should not merely be rubber stamps for fwding crazy demands from revs.
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No one is criticizing me but you. You are not all people. Unless your ego is bloated enough for you to think you are representing all.
Also, truth has nothing to do with 'reading the room' thats the job of opinion hawkers, which I am not
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wow such a mature comeback
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Is that what you are putting in your personal statement?
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is that from the transfer rate of the SD cards?