lucas.farnunglab.com - Profile | ThreadSky | a Reddit-style client for Bluesky

Schulman lab is ready for the GRK2243 Symposium: Understanding ubiquitination: from molecular mechanisms to disease in würzburg #wUeBI2025 @grk2243.bsky.social @jakobfarnung.bsky.social @samuelmaiwald.bsky.social @hannahbkmpr.bsky.social

submitted 5 days ago • 2 comments

Check out @jonmarkert.bsky.social's recent talk for the @fnucleosome.bsky.social series, covering his recent breakthrough paper (www.science.org/stoken/autho...) on co-transcriptional histone mark deposition of H3K36me3: www.youtube.com/watch?v=ByJr...

submitted 8 days ago • 0 comments

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

submitted 10 days ago • 0 comments

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s! @natsmb.nature.com 1/7 www.nature.com/articles/s41...

submitted 12 days ago • 4 comments

🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...

submitted 32 days ago • 4 comments

Watching Sven elucidate this mechanism from an unbiased screen onwards has been one of my favorite experiences as a PI. In these challenging times for science at Harvard, it reminds me of the sheer joy of doing science and making discoveries.

submitted 38 days ago • 0 comments

CONGRATULATIONS!! to @harvardcellbio.bsky.social faculty member Tommy Kirchhausen for his election to the American Academy of Arts and Sciences. So well deserved! www.amacad.org/new-members-...

submitted 45 days ago • 0 comments

Cup? Platter? Stained glass? Our imaginations were inspired (even during uncertain times!) by these beautiful molecular complexes: the Erlin and prohibitin complexes implicated in quality control at the ER and mitochondria, respectively. Check them out here: www.biorxiv.org/content/10.1...

submitted 45 days ago • 3 comments

This support is highly appreciated! From personal experience: Transatlantic cooperation is a pillar of the scientific enterprise!

submitted 46 days ago • 1 comment

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

submitted 47 days ago • 2 comments

Our research powers progress: www.harvard.edu

submitted 53 days ago • 0 comments

Check out the updated Harvard University website, which speaks to the breadth and depth of the research we do and its contributions to human health and beyond: www.harvard.edu

submitted 53 days ago • 0 comments

Amazing achievement by Spyros. Congratulations to all recipients!

submitted 57 days ago • 0 comments

Worth noting: 🇩🇪 invested 3.11% of GDP in R&D in 2023. The new 3.5% target for 2030 is only a marginal increase—and was already set for 2025. Ambition looks rather limited.

submitted 59 days ago • 0 comments

Interesting science goals from Germany’s new coalition agreement (CDU/CSU/SPD): 🇩🇪 100,000 GPU cluster for AI 🌍 “1,000 minds” program to attract global talent 📜 Another reform of fixed-term academic contracts 📈 3.5% of GDP for R&D by 2030 ⚛️ Target: First working fusion reactor to be built in Germany

submitted 59 days ago • 0 comments

Ever wonder how the human replisome engages the nucleosome? New work from the @lucas.farnunglab.com provides a striking visual tour of the process with reconstituted components!

submitted 61 days ago • 1 comment

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

submitted 62 days ago • 10 comments

Looking forward to the upcoming installation of a Krios 5 at the Harvard Center for CryoEM @hc2em.bsky.social and achieving even higher-resolution structures of dynamic transcription and chromatin complexes!

submitted 66 days ago • 0 comments

www.biorxiv.org/content/10.1... NEW PREPRINT ALERT! Thanks to all involved!

submitted 68 days ago • 2 comments

Take a look at our new collaboration project with the Phil Cole lab, we demonstrate how SIRT6 can recognize and remove a variety of different Histone acylations!

submitted 71 days ago • 0 comments

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

submitted 71 days ago • 2 comments

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay Come join us for a fun time and invigorating scientific discussions in Vienna! meetings.embo.org/event/25-rna...

submitted 75 days ago • 0 comments

Starting in 15 minutes. Join to hear all about SETD2 and H3K36me3 by @jonmarkert.bsky.social !

submitted 87 days ago • 0 comments

In 1hr…

submitted 87 days ago • 0 comments

Are you interested in hearing this SETD2 story in more detail? I’ll be presenting it at @fnucleosome.bsky.social this week! Please see the poster for more details

submitted 89 days ago • 0 comments

Join @jonmarkert.bsky.social for his Fragile Nucleosome Talk on Wednesday. He will present his fantastic work on the molecular basis of co-transcriptional establishment of H3K36 methylation.

submitted 88 days ago • 0 comments

Life science research is so important. In this rapidly changing world, the U.S. must stay at the bleeding edge.

submitted 92 days ago • 0 comments

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

submitted 103 days ago • 2 comments

Look at this crazy thing

submitted 103 days ago • 2 comments

Congratulations to our own Spyros Artavanis-Tsakonas for recieving the Wiley Prize for his work on the Notch Signaling pathway! We deserved recognition for a pioneer in developmental biology. newsroom.wiley.com/press-releas...

submitted 109 days ago • 0 comments

Excited about mechanistic biology and processes in the cell's nucleus? Join our lab as a post-doctoral researcher! We have a state-of-the-art cryo-EM facility (new microscopes coming!), a brand-new lab space, and a vibrant community at HMS! DM/email me or check farnunglab.com for more info.

submitted 127 days ago • 0 comments

Excited about mechanistic biology and processes in the cell's nucleus? Join our lab as a post-doctoral researcher! We have a state-of-the-art cryo-EM facility (new microscopes coming!), a brand-new lab space, and a vibrant community at HMS! DM/email me or check farnunglab.com for more info.

submitted 127 days ago • 0 comments

Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: www.science.org/doi/10.1126/...

submitted 128 days ago • 0 comments

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

submitted 128 days ago • 2 comments

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

submitted 129 days ago • 3 comments

Congrats, @matthiasmuhar.bsky.social and @jakobfarnung.bsky.social! Fantastic paper and very exciting new insights into protein degradation.

submitted 129 days ago • 0 comments

The entire Farnung lab is delighted that we receive continued support from @damonrunyon.org!

submitted 130 days ago • 2 comments

Only two days left to apply to the joint Epigenetics and Chromatin Architecture & Transcription Regulation meeting 👇 We're looking forward to seeing you in Banff!

submitted 151 days ago • 0 comments

Start off the New Year on a high note and submit your abstract for @KeystoneSymp Interplay of #Chromatin Architecture and #Transcription Regulation, this March/April in Banff. Short talk abstract and scholarship deadline are only 1 week away on January 9th! tinyurl.com/txn-keystone #KSChromatin25

submitted 156 days ago • 0 comments

Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing

submitted 157 days ago • 1 comment

Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA

submitted 158 days ago • 1 comment

Another highlight from our story: @jonmarkert.bsky.social uncovered how SPT6 binds the exposed H2A–H2B dimer during nucleosomal traversal by Pol II. AlphaFold helped tremendously in validating this interaction. tinyurl.com/setd2 Also check out our H2A–H2B screen: www.biorxiv.org/content/10.1...

submitted 171 days ago • 0 comments

Pol2 stimulates SETD2 methylation Of histone H3 #ChromatinHaiku #H3K36 www.science.org/doi/10.1126/...

submitted 176 days ago • 0 comments

🧪Wonderful study and visualization from @lucas.farnunglab.com and @jonmarkert.bsky.social, uncovering how SETD2 - an important but challenging cancer drug target - interacts with chromatin to catalyze H3K36me3. Congratulations to all involved!

submitted 176 days ago • 0 comments

If you like our visual biochemistry approach at the intersection of transcription and chromatin, consider applying to our lab as a post-doctoral researcher. More info here: farnunglab.com We are also always looking for Masters students to conduct their thesis research in the Farnung Lab.

submitted 176 days ago • 0 comments