lucas.farnunglab.com
Assistant Professor of Cell Biology at Harvard Medical School | Nexus of chromatin, transcription, replication, and epigenetics. farnunglab.com
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Prolific Poster
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Outstanding work from Allison James who will graduate next month! If you like our work, consider applying to the Farnung Lab. More info: farnunglab.com
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We’re deeply grateful to @harvardcellbio.bsky.social and @hc2em.bsky.social for their steadfast support. Outstanding science thrives on world-class infrastructure and a collaborative, thoughtful community.
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🧩 Our structures reveal how replisomes unwrap nucleosomal DNA in a step-wise manner. Remarkable parallels to transcription!
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Using cryo-EM and biochemical assays, we demonstrate the structural plasticity of SIRT6 engaging H3K27 modifications and highlight key adaptations that enable substrate versatility.
doi.org/10.1016/j.jb... #StructuralBiology #Epigenetics
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Anything major planned for the future?