macauleylab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Nature research paper: Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis https://go.nature.com/4e1Wek9

submitted 6 hours ago • 0 comments

Aβ-HMGB1 complex is a pathogenic molecule at the advanced stage of Alzheimer's disease https://www.biorxiv.org/content/10.1101/2025.06.12.659430v1

submitted 1 day ago • 0 comments

🚨Last week's #immunometabolism findings @biomednews.bsky.social 🔽🔽🔽 biomed.news/bims-imicid/... Interesting paper: Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells

submitted 2 days ago • 0 comments

www.nature.com/articles/s41... Early life high fructose impairs microglial phagocytosis and neurodevelopment Zhaoquan Wang et al. @nature.com 🧪

submitted 2 days ago • 0 comments

Lipid droplet dysmetabolism affects cell homeostasis in an in vitro model of Alzheimer disease https://www.biorxiv.org/content/10.1101/2025.06.09.658644v1

submitted 3 days ago • 0 comments

Super cool!

submitted 4 days ago • 0 comments

Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...

submitted 13 days ago • 0 comments

New topical review from Verity Mitchener, Mille Thackray and Lorena Arancibia-Cárcamo of @ukdri.ac.uk on the glia-immune network in health and disease, with a focus on how astrocytes and oligodendrocytes coordinate microglia in Alzheimer's disease pathology

submitted 7 days ago • 0 comments

It occurred to me today that most scientists are essentially govt contractors. The govt requested proposals for work their clients wanted performed to improve human health. We submitted applications and won the job. And now the govt is refusing to pay us for our work. Why does that sound familiar?

submitted 7 days ago • 0 comments

Cool paper on brain-body connection with lactate and physical/mental effort.

submitted 8 days ago • 0 comments

In case you needed a smile this Tuesday: 10-month-old baby KJ, who received a bespoke gene-editing therapy after a six month scientific sprint - "graduated" from the hospital @childrensphila.bsky.social today and went HOME! YAY SCIENCE! Here's his story: wapo.st/451ZQjT

submitted 13 days ago • 6 comments

🧠 Join us for the Neural-Immune Interactions / Neurodegeneration Conference — in Whistler or online via livestream! 🔗 Register now: keysym.us/KSNeuroimmun... keysym.us/KSNeuroDegen25 #KSNeuroImmune25 #KSNeuroDegen25 #neurodegeneration @michael-e-ward.bsky.social @erikaholzbaur.bsky.social

submitted 19 days ago • 0 comments

Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch @natimmunol.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

submitted 14 days ago • 0 comments

Needed to escape into art. Watercolor doodle of a Carolina Chickadee/Black Capped Chickadee. Couldn’t really tell which was dining at our bird feeders.

submitted 16 days ago • 0 comments

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

submitted 28 days ago • 4 comments

And on pages 11-12 on the MAHA report, they cherry-picked 🍒 SEER data about #ChildhoodCancer to fit their chronic disease narrative. We have the receipts 🧾 @alt-hhs.altgov.info @altnih4science.bsky.social

submitted 17 days ago • 1 comment

www.cell.com/cell/fulltex...

submitted 20 days ago • 0 comments

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

submitted 21 days ago • 2 comments

A strong statement about the importance of NIH on @cbsnews.com.web.brid.gy Sunday Morning (Part 1)

submitted 23 days ago • 1 comment

🚨 New WP! 📄 "Publish or Procreate: The Effect of Motherhood on Research Performance" (w/ @valentinatartari.bsky.social 👩‍🔬👨‍🔬 We investigate how parenthood affects scientific productivity and impact — and find that the impact is far from equal for mothers and fathers.

submitted 26 days ago • 2 comments

Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular

submitted 162 days ago • 0 comments

Sharon et al., Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 23 days ago • 0 comments

Totally love LAMP.

submitted 24 days ago • 0 comments

A systematic review and meta-analysis of group arts interventions for older adults in Nature Mental Health finds that participation in shared artistic experience was associated with lower levels of depression and anxiety. go.nature.com/4kxEQpH 🧪

submitted 24 days ago • 1 comment

We live in such a golden age of science with so much potential for discovery and alleviating some of the most severe human diseases. And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.

submitted 25 days ago • 3 comments

Age-related decline in #NAD levels impairs metabolism reducing the effectiveness of CAR-T cell cancer treatments. Study in @natcancer.nature.com shows boosting NAD in preclinical models revived antitumor properties in immune cells www.nature.com/articles/s43...

submitted 25 days ago • 0 comments

A wonderful perspective that includes the idea of cardiovascular disease as a stressor that induces sleep.

submitted 25 days ago • 0 comments

Single-nucleus multiomics in brains from Hispanic individuals reveal APOE-ε4-driven disruption of focal adhesion signaling in the presence of cerebrovascular pathology #NeuroDegeneration

submitted 26 days ago • 0 comments

This is interesting. Suggests different anti-amyloid antibodies don’t bind different forms of abeta. Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

submitted 26 days ago • 1 comment

GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy #NeuroDegeneration

submitted 26 days ago • 0 comments

Relieved, grateful, and most of excited to continue exploring how metabolic reprogramming contributes to Alzheimer’s disease progression. Thankful for our CART grant and recent NOA from the NIA to support this work.

submitted 27 days ago • 5 comments

As always, a wonderful visit and engaging discussion with @erinmgibson.bsky.social !! Fabulous researcher, stellar mentor, and superb colleague.

submitted 27 days ago • 0 comments

REMINDER.....REMINDER......REMINDER 3 DAYS LEFT TO COMMENT ON SCHEDULE F 1/n

submitted 27 days ago • 3 comments

Clonal Hematopoiesis Mutations Increase Risk of Alzheimer's Disease with APOE ϵ3/ϵ3 Genotype

submitted 27 days ago • 0 comments

Nominate a deserving early-career investigator today for a chance to attend #CCAD2026. If selected, they will compete for a $100,000, 2-year grant from #NewVisionResearch! View nomination criteria here 👉 newvisionresearch.org/ccad-2026/ Nominate here 👉 airtable.com/appjJE7FUGZY...

submitted 27 days ago • 0 comments

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉 authors.elsevier.com/a/1l7l75FFzL...

submitted 27 days ago • 4 comments

Ha! Two points: 1) this presumes I could choose one stupid way 2) that I’ve peaked

submitted 28 days ago • 1 comment

Super cool. Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

submitted 28 days ago • 0 comments