masslab.bsky.social
Based @LIMES Institute @University of Bonn, researching developmental immunology. We ❤️ macrophages!
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First authors @haohuang0086.bsky.social and Aleksej Frolov made a terrific video summary 🎥 nextcloud.dzne.de/index.php/s/...
@dzne.science
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9/ Let’s discuss! How concerned are you about plastic pollution and its impact on health? 🗣️ Drop your thoughts below! 👇 #Microplastics #Nanoplastics #ImmuneSystem #Metabolism #Science #Macrophages #KupfferCells
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8/ 💡 Why does this matter?
Our study led by the fantastic #NikolaMakdissi and @mariafviola.bsky.social highlights the immune-metabolic risks of MNP exposure. Given that humans are exposed to plastics daily, understanding their long-term effects is crucial for public health.
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7/ ❗ The long-term problem:
Even after a 6-month washout period, MNPs were still present in liver macrophages, although metabolism recovered. This raises concerns about cumulative effects over a lifetime.
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6/ 🧠 Surprisingly, even though some NPs reached the brain, we found no major changes in behaviour or inflammation. The blood-brain barrier seems to limit MP entry, keeping the brain mostly protected - at least under healthy conditions.
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5/ 🍔 When combined with a high-fat diet, MPs worsened liver fat storage, while NPs led to glucose intolerance. This suggests that chronic MNP exposure can amplify metabolic disorders.
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4/ 🆚 Size matters!
#Microplastics (MPs, 500 nm): Impair KC-dependent phagocytosis (platelet-depletion assay), increasing liver lipid accumulation (Oil-red-O, ORO staining).
#Nanoplastics (NPs, 50 nm): Affect glucose metabolism and reach the brain, but don’t trigger neuroinflammation.
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3/ 🔬 Using a chronic exposure model in mice, we found that liver-resident macrophages (Kupffer cells, KCs) are the primary site of MNP accumulation. Over time, this disrupts their function, leading to metabolic imbalances in the liver and beyond.
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2/ 🧐 The big question:
We know MNPs are in food and water, but how do they interact with our immune system and organs? Specifically, what happens when they accumulate in macrophages—the immune cells that regulate metabolism?
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sorry for the auto-correction mistake! Of course this is from the Sancho lab!!! @sancholab.bsky.social 😆
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It would have been nice to have an immunologist reviewing this who could have told the authors that macrophages do not circulate and that neutrophils do not express F4/80....
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by regulating blood and cerebrospinal fluid flow, and are implicated in neurodegenerative processes, including amyloid deposition and calcification…
www.cell.com/trends/immun... @cellpress.bsky.social
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