mathpreu.bsky.social
PhD in the lab of @vlecaudey.bsky.social at JGU. Developmental Biology in #Zebrafish.
76 posts
654 followers
949 following
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Awesome series of extraordinary images😍
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Been there 2023...it definitely was a great experience 🔬🧬
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Congratulations 🙂↕️🥳
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Awesome thread 🧵 and what a cool story
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stunning image🔬
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Awesome image😍
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You just made my day....🤩thank you so much 🙂↕️
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You're the best thanks 🤝😍
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Beautiful 😍
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Cuttlefish looks amazing 😍
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It's crazy how many details there are in a single image🤩
Those patterns actually remind me of the ones on old bus seats from the '90s .... finally I know what inspired them😂
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Awesome image🦎
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I love hearing that 🤩 Honestly, it was the stunning complexity, that made me want to explore the organ more deeply
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You're too kind. Thank you 🤝
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Thank you Ina 😊
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Thanks for sharing 🤝
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I deeply appreciate that—I'm truly grateful for the support and encouragement 🤝
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Love the magnified one 🤩
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One region magnified below — the detail you can achieve with Airyscan is just fantastic! @zeiss-microscopy.bsky.social
Shout out to the core: @nat-prunet.bsky.social
& the LUT-maker: @kwolbachia.bsky.social
#FluorescenceFriday #cellbio #microscopy #devbio #fiji #imagej
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10)
Now, if you're interested in seeing the full developmental journey of zebrafish gills—from arteries to filaments to lamellae—you can check out the preprint here: www.biorxiv.org/content/10.1...
Big thanks to everyone involved—especially to @vlecaudey.bsky.social
#zebrafish #microscopy #devbio
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9)
Gills offer a powerful model to study angiogenesis, blood pressure, (NC) stem cells, and branching morphogenesis in vivo. Our work provides a detailed framework to explore these complex processes. We anticipate this resource will serve as a foundation for future functional & mechanistic studies
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8)
In adult fish no new filament are being added. Exisiting ones only increasae in their size
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7)
Pillar cell number and lamellar size reflect developmental asymmetries but are modulated by dorso-ventral position and filament identity (medial or lateral). Our findings suggest that the structural asymmetry correlates with functional roles of filaments and lamellae in optimizing gas exchange.
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Additionaly we examined the development of gill lamellae, the sites of gas exchange, which arise through coordinated interactions between endothelial cells and neural crest-derived pillar cells.
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Using live cell microscopy we showed that gill filaments form asymmetrically along the dorsoventral axis: dorsally, medial filaments emerge first and are longer; ventrally, lateral filaments form before medial ones. These early patterns predict adult gill architecture.
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4)
To examine filament morphology in greater detail, we combined kdrl:mCherry (red) with the recently described fgf10b:nEOS (white)-shoutout to @fabianlab.bsky.social -. kdrl:mCherry labeled the gill vasculature, while fgf10b:nEOS revealed the pillar cell nuclei within the lamellae.
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3)
kdrl:mcherry revealed a consistent medio-lateral asymmetry in filament length along the dorso-ventral axis: medial filaments were longer than their lateral counterparts (pseudo-coloured white), except in the ventral-most region of the arch where lateral filaments were longer.
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2)
For the first time, we characterize the lifelong development of zebrafish gills—from arteries to filaments to lamellae—using high-resolution microscopy, providing a detailed quantitative framework for these complex processes.
Dive into the full study: www.biorxiv.org/content/10.1...