mossi-lab.bsky.social
Mosquitoes, Wolbachia, gut microbes, microbiomes, arboviruses, Plasmodium. Liverpool way. 🦟🦠
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And finally a huge congrats to Aidan and Shannon for both winning poster prizes!
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Shannon presenting his recently published work on parasitic nematode specific RNA viruses and their role in antibody responses in vertebrate hosts. Also joined by our MRes student Sernyen.
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@aidanfoo.bsky.social presenting on the contribution of siderophore mediated competition to Aedes aegypti colonisation
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@luciendobel.bsky.social presenting on the role of the microbiome in Aedes aegypti oviposition site preference.
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Us too please.
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Would be great to join - thanks.
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Could we join too please?
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Would be great to join - thanks.
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Fantastic if we could join...
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Would love to join please.
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Us too please...
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MosAIC is a collaborative effort! Learn more and get involved here: kcoonlab.bact.wisc.edu/mosaic/. #Collaboration
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🌱 We plan to expand MosAIC by isolating bacteria from field-derived samples from disease-endemic areas and capturing genomic representation from fungi/protozoa. Also apply more selective culturing and metagenomic approaches to capture a broader taxonomic range in future iterations of this collection
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🧬 To further investigate, we conducted a pangenome analysis, identifying sets of lineage-specific genes in mosquito-derived bacteria. These suggest potential selection for life in a mosquito environment and are exciting candidates for future research on mosquito-microbe interactions #Pangenomics
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🌍 Phylogenetic analysis revealed clustering of mosquito-associated bacteria within three genera: Enterobacter, Serratia, and Elizabethkingia. These genera include lineages derived from mosquito hosts, that may reflect bacterial adaptation #Phylogenetics #Evolution
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🧫 Genomes were screened against the virulence factor database, revealing genes related to adhesion, biofilm formation, and others. We also noticed a heavy bias towards the Enterobacteriaceae, highlighting the need for better virulence factor representation of non-model microorgs #VirulenceFactor
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📊 Our genomes are high quality, with completeness averaging 99.67% and contamination below 0.6%. We also report metrics like N50, genome size distribution and correlations with the number of predicted gene. #QualityControl #GenomeQualityAssurance
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🔍 MosAIC encompasses 142 bacterial species across 29 families. Bacteria were sourced from a range of mosquito species, life stages and locations. Collection curation was led by teams in UW-Madison and The Liverpool School of Tropical Medicine.