nebanovich.bsky.social
Associate Professor at TGen.org. Interested in genmoics, single cell and spatial transcriptomics, lung disease, and oftentimes fishing. banovichlab.org
156 posts
1,367 followers
1,205 following
Prolific Poster
Conversation Starter
comment in response to
post
I did search the text of the bill this morning and there is no mention of the NIH in the text. I also asked ChatGPT to summarize any provisions related to NIH and it didn't come up with anything. Take that for what it's worth I guess...
comment in response to
post
Very cool work Tuuli!
comment in response to
post
Major congrats and so well deserved @jkpritch.bsky.social. I'll always be grateful for your amazing mentorship!!
comment in response to
post
The HHS secretary's office apparently also said that NIH should NOT PROVIDE ANY INFORMATION to these
schools about whether or why the funds are frozen.
Radical transparency, my ass.
2/3
comment in response to
post
This is the product of a fantastic collaboration, building on 8 years of work w/ Christine Brown. However, the true superstars of this study are @heinimnatri.bsky.social from my group and Sherri Gholamin from Christine’s. They did an amazing job leading this study and I’m so proud of the work.
comment in response to
post
Finally, we demonstrate that blocking SPP1 in the JAK1 KO model and a mouse glioma model resulted in dramatic therapeutic improvement and broad remodeling of the suppressive TME. We are excited to push this work forward and work to improve outcomes for patients with solid tumors.
comment in response to
post
Mimicking results from our human studies, the JAK1 KO model showed striking resistance to CAR T therapy. Again, SPP1 signaling was a dominant feature of the TME signaling in these tumors.
comment in response to
post
To extend these findings to other solid tumors we turned to an IFN deficient JAK1-knockout mouse model of melanoma. In this model we also found an immunosuppressive myeloid cell population emergent in the IFN deficient mice but not the WT tumors.
comment in response to
post
Looking deeper at SPP1 we found increased expression is associated with broad remodeling of the myeloid compartment – including emergent immunosuppressive phenotypes, a changed metabolic profile, and a reduction in inflammatory IL/IFN signaling
comment in response to
post
Our analysis found that SPP1 signaling between myeloid compartment and fibroblasts was increased in patients with worse outcomes and lower CD3 infiltration.
comment in response to
post
We first used single cell RNA sequencing to characterize tumors from PRE-TREATMENT patients from our recently published phase 1 trial (led by the amazing Christine Brown and Behnam Badie) using an IL-13Rα2-targeting CAR-T to treat patients with high grade gliomas. www.nature.com/articles/s41...
comment in response to
post
Right back at ya! See you at ATS in May.
comment in response to
post
Kids Cuisine with a brownie cooked by the microwave covered in plastic wrap tastes like my childhood.
comment in response to
post
Congrats Anna!