peterlewislab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

New from our lab & @harrisonflylab.bsky.social: Drosophila models of H3 K27M & EZHIP reveal conserved chromatin regulators that buffer PRC2 inhibition. An in vivo screen highlights how developmental defects can be rescued despite global H3K27me3 loss. doi.org/10.1101/2025...

submitted 11 days ago • 1 comment

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

submitted 17 days ago • 0 comments

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

submitted 26 days ago • 2 comments

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

submitted 38 days ago • 14 comments

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

submitted 43 days ago • 5 comments

Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social Very happy to see this come to fruition- Look forward to feedback from colleagues ! More 👉 www.cell.com/cell/fulltex...

submitted 45 days ago • 3 comments

This is so beautiful. Sincerely, Genetics professor From: www.nature.com/articles/s41...

submitted 59 days ago • 1 comment

New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons www.biorxiv.org/content/10.1...

submitted 70 days ago • 2 comments

Happy Polycomb Day (3/27)! Today we celebrate H3K27me3- Polycomb’s quiet mark of repression, where gene silencing is not neglect, but a deliberate act of identity.

submitted 72 days ago • 1 comment

In this study, Wolf van der Meer et al. show that USP7 plays an essential role in neuronal differentiation by regulating BCOR–ncPRC1.1 dosage and repressive H2AK119ub1 deposition. Learn more here: ➡️ tinyurl.com/gd352272

submitted 81 days ago • 0 comments

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...

submitted 85 days ago • 2 comments

Congrats @automnenine.bsky.social and @kellythd-nguyen.bsky.social ! www.science.org/doi/10.1126/...

submitted 93 days ago • 0 comments

Awesome summary of the field. An important point is to separate the design method from the oracle model being used. Sometimes, people say they're proposing a new design method but mean a cool new oracle model. Modelling and design of transcriptional enhancers www.nature.com/articles/s44...

submitted 96 days ago • 1 comment

Intriguing paper from @nimamlab.bsky.social. Adding to the 'read in detail' list. www.cell.com/molecular-ce...

submitted 96 days ago • 2 comments

www.biorxiv.org/content/10.1...

submitted 99 days ago • 0 comments

The NIH website and related platforms like PubMed are currently down. Has anyone heard any updates on what’s going on or when they might be back online?

submitted 98 days ago • 1 comment

Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...

submitted 109 days ago • 0 comments

For our latest paper, we worked with SYROS Pharmaceuticals, the groups of Dylan Taatjes and Robin Dowell at CU Boulder, and @abhaykot.bsky.social. Junjie Feng in my lab determined the #cryoEM structure of the CDK7 inhibitor SY5609 bound to its target... www.science.org/doi/10.1126/...

submitted 99 days ago • 5 comments

🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵 www.nature.com/articles/s41...

submitted 108 days ago • 7 comments

22 states have filed suit to stop the NIH’s decision to slash indirect cost to 15%. This cut would have forced universities and medical institutions to lay off staff, shut down labs, and halt critical research on diseases by stripping away funding for lab space, equipment, and regulatory compliance.

submitted 117 days ago • 2 comments

NYGC is organizing a number of efforts to address the changes to NIH IDCs and other changes to federal policy. If you are a US citizen, or in the US working in science, please consider signing this petition. The more signatures the stronger our hand in interacting with law makers. chng.it/kK2HMP5pGk

submitted 117 days ago • 2 comments

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

submitted 120 days ago • 3 comments

Another crazed change from the Trump Administration: removing the NIH No-cost extension form

submitted 122 days ago • 3 comments

Our new #preprint has: ✅ A KRAB Zinc Finger (the SCAN domain-containing kind) ✅ #transposon sequences (the SINE kind) ✅ #epigenetic regulation (the #enhancer kind) ✅ lineage specification (the neural kind) ❌ and NO heterochromatin! All by PhD student Daniel Moore 🚀 www.biorxiv.org/content/10.1...

submitted 121 days ago • 3 comments

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...

submitted 122 days ago • 1 comment

Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....

submitted 130 days ago • 0 comments

New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions www.cell.com/molecular-ce...

submitted 141 days ago • 3 comments

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

submitted 141 days ago • 8 comments

Our latest work using TIRFM to uncover mechanisms that stabilize the centromeric nucleosome: www.embopress.org/doi/full/10....

submitted 144 days ago • 0 comments

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

submitted 144 days ago • 3 comments

New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1... For a quick summary see this 🧵 1/8 #epigenetics

submitted 149 days ago • 3 comments

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

submitted 155 days ago • 1 comment

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

submitted 156 days ago • 10 comments

Chromosome missegration activates dsRNA-sensing pathway in a MAVS-dependent manner and enhances innate immune signaling! www.cell.com/molecular-ce...

submitted 157 days ago • 0 comments

Structural insights into how Cas9 targets nucleosomes www.nature.com/articles/s41... ▶️ Cas9 targets the linker DNA and the entry-exit DNA region of the nucleosome but not the DNA tightly wrapped around the histone octamer

submitted 158 days ago • 0 comments

The structural basis for de novo DNA methylation in chromatin www.biorxiv.org/content/10.1... ▶️DNMT3A2/3B3 preferentially binds di-nucleosomes separated by short DNA linkers ▶️Linker length and position of cytosines control DNA methylation ▶️a large fraction of linkers is resistant to DNMT3A2/3B3

submitted 160 days ago • 1 comment

Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...

submitted 160 days ago • 0 comments

Boundaries between TADs often extend over considerable distance. But how variable is this width of boundaries? And does it matter? Find out in our new pre-print with the group of David Holcman. www.biorxiv.org/content/10.1...

submitted 163 days ago • 2 comments

Epigenetic memory that couples 5mC and H3K9 methylation, enables chromatin state inheritance across lifetimes and evolution. New excellent review by @hitenmadhani.bsky.social highlights inheritance mechanisms including roles for histone chaperones and nucleosome recycling. tinyurl.com/42ddhj4a

submitted 165 days ago • 0 comments

Our preprint from earlier this year on the oxidation-induced mutational landscape in human cells was just published! www.nature.com/articles/s41... I’m still amazed how much chromatin structure impacts oxidation-induced mutagenesis. Our cryo-EM contribution in this work provides a glimpse into why!

submitted 166 days ago • 1 comment

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

submitted 169 days ago • 4 comments

#InterferonPower! Fantastic @science.org by @nandangokhale.bsky.social @ramlabuw.bsky.social &co! MAVS is intrinsically capable to sense via an unstructured region the 3’ UTRs of self mRNA (ISGs too!) to potentiate the response to viral RNA via phosphorylation of IRF3 & NFkB!

submitted 170 days ago • 0 comments

www.nature.com/articles/s41... (1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀 Check out our latest collaborative work with the Soufi lab, now published in @Nature

submitted 171 days ago • 1 comment

Epigenetics drives cell identity inheritance, while epigenomics focuses on DNA’s structural partners that regulate gene activity. Understanding the difference clarifies how cells maintain their type across generations. www.cell.com/trends/genet...

submitted 225 days ago • 0 comments

This is a great essay by Martin Schwartz on the importance of embracing "productive stupidity" in science. Feeling uncertain is part of the research process, pushing us deeper into the unknown and closer to discovery. journals.biologists.com/jcs/article/...

submitted 271 days ago • 0 comments