rexjiang.bsky.social
Evolutionary biologist; postdoc @oistedu.bsky.social; evolutionary theories | complex traits | evolutionary novelties
Views are my own.
https://rexjiang385518549.wordpress.com/
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In my case the game is Fate/GO, which makes me wonder how come our world isn’t a lostbelt (i.e. a world with no future and destined to be ‘trimmed’ from the reality by multiverse managers)
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…but with tiny effective population size and considerable genetic load…
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The truth behind the whole franchise (and many others)🤣
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The fight would be BLOODY, at least among Chinese Gundam fans…😂
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他在离任UM校长的时候还把他的名字从一众校长联署的、支持学术自由的公开信上撤去了。结果还是没能让佛罗里达共和党满意😂
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被骂的这位还是作者之一，想必也没好好看内容😂
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I’m in Japan time zone but not much better off 😂(my Japanese is far from good enough to watch the unsubbed version on Netflix here)
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语法确实很简单
句子的内容很有时代感😂
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Japanese law *requires* a married couple to have the same last name. In a vast majority of cases it's women that change last name. Ironically, I've seen Chinese netizens mocking Japanese as conservative because of this, despite China is more socially conservative in many other ways.
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我来日本不到一年，日语也不怎么样，信用卡也办了。看来是王志安在给中国人丢脸啊😂
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Congrats! This looks cool!
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I almost wished Trump were the Pope *instead of* US president when seeing this... But what these lunatics want is a "Pope-US president combination".
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I’m reminded of the days during which I could walk into the museum from next door 😭
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I find the ‘T. rex beach’ from this angle looks vaguely like a crocodilian head 😂
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Was fortunate to be able to go there when I was in LA. Really enjoyed. (This one beside had an extra bone😆)
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Revenge!🤣
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This finding shows different optimization strategies: at moderate Ne, a global solution is selected for, as local optimization is impossible in face of mutational pressure and drift; at large Ne, local optimization of cis- loci is possible, and constraint is lifted. 8/8
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We show a non-monotonic scaling of modification activity and effective population size. At small Ne, only overall activity responds to selection on modifications, so mod activity declines w/ Ne. At large Ne, cis-loci start to respond, so overall activity can be optimized. 7/8
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We also examined evolutionary dynamics when the modification processes is under opposing selection forces: it causes deleterious modifications, but has another function and has to be retained. How will the modification activity evolve then? 6/8
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We show that the level of such a deleterious isoform declines with effective population size, expression level, and interestingly, the number of cis- loci--when there's a large cis- mutational target, optimization becomes harder. 5/8
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In this model, gene product modification is affected by a trans-factor (modification enzyme) and a set of cis-loci (binding motif). We specifically asked how the relative abundance of a non-functional, toxic isoform (I1 in panel A and I2 in B) scales with evolutionary parameters. 4/8
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What we did here is to develop theoretical model and show how different evolutionary processes leave distinct signatures in variation of isoform abundances. 3/8