ronbeavis.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

If youre new to this rodeo: there is no country which is in a position to really take advantage of this. Canada does not substantially underperform Europe/Japan /Korea/Oz in terms of recent HE investments. China is maybe a partial exception but has other things going against it as a destination.

submitted 1 day ago • 5 comments

A blob of potentially unpleasant weather is making its way through Dixie at the moment.

submitted 7 hours ago • 0 comments

Are the lysosomal enzymes that appear in urine & CSF secreted separately or is there a little bag manufactured in some cell types that serves as a secretory equivalent of a lysosome?

submitted 10 hours ago • 1 comment

Iduronate 2-sulfatase (IDS:p) rips the sulfate groups off the iduronate moieties in heparin or dermatan sulfate in lysosomes. #proteomics ✔ 33 aa signal + propeptide ✔ no observed PTMs; ✔ observable in urine or CSF; & ✔ AF structure with imaginary N-terminal tail.

submitted 10 hours ago • 1 comment

Alpha-L-fucosidase 1 (FUCA1:p) is a lysosomal exoglycosidase that is part of that organelle's complex carbohydrate wrecking crew. #proteomics ✔ 31 aa signal peptide ✔ no observed PTMs; ✔ plenty to see in urine; & ✔ AF structure complete with fantasy signal peptide.

submitted 1 day ago • 2 comments

L’administration Trump retire à l’université Harvard le droit d’accueillir des étudiants étrangers, et demande le transfert des milliers d’élèves actuellement concernés

submitted 2 days ago • 9 comments

Moderna pulls application for U.S. approval of COVID-flu shot globalnews.ca/news/1118962... @reuters.com 𝗠𝗼𝗿𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗻𝗲𝘄𝘀 ⇢ CanadaHealthwatch.ca 🍁

submitted 2 days ago • 2 comments

The Trump administration is blocking Harvard from enrolling any international students, and I would expect this to be extended to at least the Ivies and possibly beyond over the next several weeks. This is a big move.

submitted 2 days ago • 1 comment

You will all be receiving a single mandate letter from me soon.

submitted 2 days ago • 4 comments

Mannosidase beta (MANBA:p) is a lysosomal exoglycosidase that pops mannose off N-linked glycosylation like candy from a Pez dispenser. #proteomics ✔ 18/19 aa signal peptide ✔ no observed PTMs; ✔ commonly found in urine; & ✔ AF structure with a non-existent signal peptide.

submitted 2 days ago • 1 comment

reproducible.cs.princeton.edu

submitted 3 days ago • 1 comment

GM2 ganglioside activator (GM2A:p) is a lysosomal co-enzyme that grabs some gangliosides so that β-hexosaminidase A can remove their HexNAc's. #proteomics ✔ 23 aa signal peptide + 10/11/12 aa propeptide; ✔ no significant PTMs; ✔ lots in urine; & ✔ AF structure with a phony signal/pro peptide.

submitted 3 days ago • 0 comments

Oof. Truth.

submitted 5 days ago • 0 comments

The soil temperature has gotten in to the range where some garden crop seeds (beets, chard, peas, radishes, parsley) will germinate. #winnipeg

submitted 4 days ago • 0 comments

N-sulfoglucosamine sulfohydrolase (SGSH:p) is a lysosomal enzyme that chops sulphates off things like heparin sulphate. #proteomics ✔ 20 aa signal peptide; ✔ a smidge of PTMs; ✔ abundant in urine; & ✔ AF structure with a mirage N-terminal signal peptide.

submitted 4 days ago • 1 comment

#proteomics tip: if you want to find high occupancy S/T+phosphoryl acceptors, you can't go wrong looking for S/T residues wedged between short low complexity regions with different side chain charges. If there are a few prolines scattered around, it's a party! PRPLKKRSSITEPEGPG

submitted 5 days ago • 1 comment

Spain's consumer rights ministry blocks more than 65,000 Airbnb listings for holiday rentals Authorities blame Airbnb for exacerbating housing shortages and pushing up real estate prices www.cbc.ca/news/world/s...

submitted 5 days ago • 2 comments

Hexosaminidase subunit alpha (HEXA:p) is a lysosomal enzyme that bites terminal N-acetyl hexosamine (e.g. GalNAc) off complex carbohydrates. #proteomics ✔ 22 aa signal peptide; ✔ very lite on PTMs; ✔ common in urine; & ✔ AF structure with phantom N-terminal signal peptide.

submitted 5 days ago • 1 comment

In these uncertain and turbulent times, it's reassuring to know that we can count on the Maple Leafs to collapse in the playoffs, right on schedule.

submitted 5 days ago • 55 comments

This week, the GOP slid an amendment into the budget reconciliation process that would ban US states from enacting laws that govern AI. This of course was not an aberration—it’s the direct result of Silicon Valley lobbying efforts, and big tech’s union with Trump and the Republican Party.

submitted 8 days ago • 15 comments

Another great cartoon worth sharing ...

submitted 6 days ago • 0 comments

www.halifaxexaminer.ca/commentary/a...

submitted 6 days ago • 0 comments

Lipase A, lysosomal acid type (LIPA:p) is a lysosomal enzyme that turns low density lipoprotein particles into free lipids. #proteomics ✔ 27 aa signal peptide & 49 aa propeptide; ✔ hint of PTMs; ✔ very rare in urine; & ✔ AF structure with a spectral N-terminal signal peptide.

submitted 6 days ago • 1 comment

It should be clear by now that "just apply for more grants" cannot be considered good advise much longer. What do other institutions discuss re: how to support pre-tenure (and post-tenure) to meet the grant requirement or, quite frankly, to continue running their labs?

submitted 8 days ago • 1 comment

Literally, all the early career funding opportunities are going away or being drastically reduced, and people are still saying “apply for more grants” to those whose grants were terminated 🤷🏾‍♀️

submitted 8 days ago • 6 comments

“innovation”

submitted 18 days ago • 8 comments

It periodically annoys me that this system does not allow editing of posted blurbs.

submitted 7 days ago • 0 comments

Aspartylglucosaminidase (AGA:p) is a lysosomal enzyme that bites off N-linked glycosylation at the Asp sidechain. ✔ 23, 24 or 26 aa signal peptide (ragged N-terminus); ✔ light smatter of PTMs; ✔ frequently observed in urine; & ✔ AF structure with the ghost N-terminal signal peptides past.

submitted 7 days ago • 1 comment

Seems to be quite a bit more potential for seeing the #aurora than I was expecting this evening.