smithlabumbc.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team. Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵 www.biorxiv.org/content/10.1...

submitted 19 days ago • 4 comments

Daily dose of 🌈, neighborhood Pride Crawl edition.

submitted 19 days ago • 0 comments

With all the craziness that's been happening, I am pleased to announce that our new UMBC-UMB Chemistry-Biology Interface (CBI) T32 was awarded today by NIGMS for five years! I know we've been disheartened to see the "T32 flat line" for new grants, but I am happy this bumps it up...a bit...

submitted 21 days ago • 4 comments

@getacrystal.bsky.social & SSRL are out in force teaching at the New Opportunities for Structural Biology Research Workshop in TN this week! Thanks Jamaine Davis for making the workshop happen & the invite! Nice work @gabbygrowsxtals.bsky.social, Tiffany, Darya & Crissy! @ubuffalo.bsky.social

submitted 24 days ago • 0 comments

Gabrielle R. Budziszewski et al.: Preparing for successful protein crystallization experiments #Crystallization #XRayCrystallography #StructuralBiology ... #IUCr https://journals.iucr.org/paper?S2053230X25004650

submitted 24 days ago • 0 comments

If you don't know @xtalmaker.bsky.social and their amazing facility at UBuffalo to help you achieve your crystallization goals, you should!

submitted 25 days ago • 1 comment

Welcome to June! Here’s your first daily dose of 🌈.

submitted 26 days ago • 0 comments

Happy Pride Month #cat #pride #pridemonth 🏳‍🌈

submitted 26 days ago • 133 comments

Presidential budget is out. Here's NSF. Biggest cut, by amount, is $1 billion, or 66.8%, from MPS (Physics & Math directorate). nsf-gov-resources.nsf.gov/files/00-NSF...

submitted 28 days ago • 31 comments

I feel it is important context that the President's budget proposal is for Fiscal Year 2026 (as noted in this Research!America comment) www.researchamerica.org/press-releas... Congress (both House and Senate) must still act to make these law. We have between now and September to stop this madness.

submitted 27 days ago • 0 comments

Protein degradation in E. coli via N-terminal degradation signals (degrons) defined by the @kunjapur.bsky.social lab. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

submitted 35 days ago • 0 comments

I’m very excited to share our latest publication characterising the substrate binding interactions of an N-terminal cysteine oxidase (NCO), out now in @natcomms.nature.com! doi.org/10.1038/s414...

submitted 35 days ago • 3 comments

Our surgery patient came through with flying colors!

submitted 37 days ago • 1 comment

New Title Alert: NMRFx Analyst- a tool for NMR processing, visualization and analysis that integrates code of NMRFx Processor, Structure and additional tools. Learn more here: buff.ly/3agOa60 #SBGrid #Software #StructuralBiology

submitted 38 days ago • 0 comments

With the @lindorfflarsen.bsky.social group we present our map of degrons in all human transcription factors, incl. examples of constitutive degrons in exposed regions & buried degrons that are exposed upon mutation. In addition, we show that most TADs overlap with degrons. Work led by Fia Larsen.

submitted 40 days ago • 0 comments

Here's one to add to your Friday reading list! 🚨Just in press in J. Mol. Biol.🚨: a beautiful review on the structures, mechanisms, regulation, and open questions of aminoacyl-tRNA-protein transferases by Misti and Rajat who work on amino acid transferases! Read the paper here: tinyurl.com/mr386wsn

submitted 42 days ago • 0 comments

LMAO Cytiva has the nerve to send an email for a “tariff surcharge”…on an upcoming preventative maintenance visit…that has already been quoted, contracted, and paid in full last year. Girl, bye 💅

submitted 42 days ago • 0 comments

I'd love to guest lecture at a college or university in the DMV area. I can teach about biology (introductory or advanced cell/molecular topics) or communications (science communications or social media). My inbox is open for collaboration and networking! 🧪

submitted 43 days ago • 1 comment

It was definitely time for a new group photo, and little Aldo (center) stole the show!

submitted 46 days ago • 0 comments

NSF to ONLY fund research in five areas: artificial intelligence, quantum information science, biotechnology, nuclear energy, and translational science. Can this be happening? www.science.org/content/arti...

submitted 48 days ago • 23 comments

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

submitted 49 days ago • 8 comments

No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...

submitted 49 days ago • 1 comment

💥Latest preprint from our lab is now live! We propose a crazy(!?) new mechanism for how the radical SAM enzyme Elp3 (a subunit of the Elongator complex) modifies tRNA! #RNAsky #enzymes 🧵...

submitted 50 days ago • 2 comments

🚨 New PARTI trick: NAR #Breakthrough article from cgemcci.bsky.social describes a new technique for studying tRNA acylation 🚨 👉 Introducing '3-Prime Adenosine-Retaining Aminoacyl–tRNA Isolation (PARTI)'. 📖 Read the full article here: doi.org/10.1093/nar/... #tRNA #Translation - Part 1

submitted 50 days ago • 1 comment

🧪 ICYMI: $25,000 bridge funding for terminated NSF grants. Major props for to the Spencer, Sloan, W. T. Grant, and Kapor Foundations for their swift action, even though we (and they) know this is a band-aid fix. Due May 30. Applications are brief: a 2-3 page memo of 6-month plans & other docs.

submitted 52 days ago • 2 comments

Wow! And only 3 yrs into its publication!

submitted 52 days ago • 0 comments

Tingfei Chen et al.: Structure of an Fe2+-binding-deficient mimiviral collagen lysyl hydroxylase #PostTranslationalModifications #DNAViruses #Dioxygenases @MedUniGraz...#IUCr https://journals.iucr.org/paper?S2053230X25003735

submitted 55 days ago • 0 comments

And NSF Indirects now "set" to 15%. What a day.

submitted 55 days ago • 0 comments

A devastating proposed budget, that includes a 40% cut to NIH and a 50% cut to NSF. If enacted, this proposed budget would decimate American science. www.npr.org/2025/05/02/n...

submitted 56 days ago • 0 comments

And now Anatrace...8% surcharge on, well, everything 🫠

submitted 56 days ago • 0 comments

MilliporeSigma to institute a tariff surcharge on May 5

submitted 56 days ago • 4 comments

Oh, goodie—now a tariff surcharge for Millipore Sigma products. 🫠

submitted 56 days ago • 0 comments

RFK Jr. has just decided to take $500 million from the HHS budget and hand it to two of his buddies to develop a universal vaccine. At this time, there is precious little scientific evidence to support this project. www.cbsnews.com/amp/news/cov...

submitted 57 days ago • 30 comments

Staff members at the US National Science Foundation (NSF) were told on 30 April to “stop awarding all funding actions until further notice,” according to an email seen by Nature. https://go.nature.com/44Ugf9V

submitted 56 days ago • 7 comments

I feel VERY seen...

submitted 60 days ago • 3 comments

Yet again, UMBC proud!! 🤩

submitted 63 days ago • 1 comment

www.science.org/content/arti...

submitted 64 days ago • 0 comments

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.

submitted 64 days ago • 1 comment

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

submitted 65 days ago • 18 comments

🤮

submitted 67 days ago • 0 comments

The Pseudomonas aeruginosa Membrane Histidine Kinase BqsS/CarS Directly Senses Environmental Ferrous Iron (Fe2+) https://www.biorxiv.org/content/10.1101/2025.04.06.647434v1

submitted 81 days ago • 0 comments