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spyroslytras.bsky.social
Evolutionary Virologist based at the University of Tokyo 🇯🇵 💻🦠🏳️‍🌈
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Planning to apply for #research #funding from the ERC? From the next application rounds, expect changes to the: • proposal structure • evaluation process • extra funding you can request • eligibility for Starting & Consolidator #Grants (from 2027) More 👇 europa.eu/!RPHWvv

I wrote a new thing about Bobby Kennedy's crusade against vaccines in the context of H5N1. He trashed Moderna, and if there's a pandemic, he'll cash in on that decision. rasmussenretorts.substack.com/p/great-week...

How bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)

very nice work from the @fviromics.bsky.social and Baric labs uncovering some of the ways these merbecoviruses can use ACE2 as their entry receptor! www.nature.com/articles/s41...

Our study screening the majority of all published Merbecovirus RBD’s for cell entry phenotypes is now published in Nature Communications! (1/5) shorturl.at/gYz4E

You might be wondering why we haven't updated outbreak.info for months. Well, the reason is that GISAID cut our access in January - as they did others. Without telling us. After a ♾️ back and forth, that is now permanent. More on that soon - and why GISAID should not be trusted with critical data.

Target-rich environment, this speech. 1/n

Happy to share this interview with Weijie Zhao from NSR at #OxfordUniversityPress. It covers questions I’m often asked—why I chose Korea, AlphaFold2, my unconventional journey into academia, and research insights. Thanks again for the fun conversation. 📄 academic.oup.com/nsr/article/...

A wee summary of our paper: Tim and Juraj’s landmark paper from 2020 was the first to elucidate the structural and biochemical detail of RNF213, the largest known E3 and only AAA-E3 hybrid. Among many observations, two stood out: E3 activity was RING-independent and specific for the E2 UBE2L3.

Delighted to give the first talk of my PhD at the UK Hepacivirus and Flavivirus Meeting over the weekend, where I talked about using ML to understand arbovirus evolution 🦟! Thank you to the organising committee and in particular my supervisors @maringerlab.bsky.social & @grovearmada.bsky.social

Outbreaks of Marburg virus (MARV) disease have been increasingly more frequent recently. Here we describe a prefusion-stabilized MARV GP and a best-in-class MARV neutralizing antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

EXCITING NEWS – Nature Health Global is delighted to announce a SURPRISE dollar-for-dollar match “Challenge Fund” from an anonymous donor today naturehealthglobal.org/exciting-new...

Had a great fun at @rdrpsummit.bsky.social! The field of RNA virus discovery is gaining momentum and this community is in the forefront. New ideas and collaborative projects begin here, usually from a friendly conversation :)

The CoVFit paper is now published @natcomms.nature.com !! Exciting work led by Jumpei Ito really showing the potential of pLMs for genotype-2-phenotype predictions!! www.nature.com/articles/s41...

Today, the ERC formally adopted a decision to increase its support for researchers moving to Europe. On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe. This extra funding is now x2 (up to €2 million!) europa.eu/!6Vdgmp

Spoke with Katy Brown at ViBiom @evbc.bsky.social —she’s uncovering the hidden diversity of RNA virus RdRp fossilized as endogenous viral elements (EVE). “We’ve only begun to uncover their true diversity.” www.biorxiv.org/content/10.1...

What a great few days at #ViBioM2025 seeing the latest in virus bioinformatics and meeting the awesome people that made it. Stunning setting at Lisbon Instituto de Higiene e Medicina Tropical🦟💉, great company 🎉 and great science 🧬💻! Bring on next year's meeting @evbc.bsky.social!

The world’s richest people are disproportionately responsible for climate impacts such as extreme heat and drought https://go.nature.com/4jYZGhW

Another week another conference!🎯 #ViBioM2025 here we go! Looking forward to hear and talk about the newest virus bioinformatics developments!👩🏽‍💻 But first enjoying the beautiful city of Lisboa. What a work-life balance!☀️

Great time in Lisbon so far at @rdrpsummit.bsky.social ! Looking forward to another day of great talks and discussing the future of RNA virus discovery! + #ViBioM2025 starting tonight! Can't wait to see lots more friends! 😁😁

Are you ready for day 2 of the #RdRpSummit2025??

RNA Viromes of subways and other urban biomes by Alexander Lucaci! #RdRpSummit2025

Introducing the #ICTV taxonomy challenge , Cedric Lood! #RdRpSummit2025

Great thread by Spyros on this long-in-the-making paper which I also contributed to — a deep dive into the timing and origins of both SARS-CoVs👇

A great thread on such an important paper. One that really helps us take a more holistic look at sarbecovirus diversity and recombination-directed evolution in the horseshoe bat reservoir. Ignoring won't help, as I can't imagine the last chapter on human spillover of these has been written.

Sooo happy to finally have this one published!! (3 years in the making… 👀) A comprehensive investigation into the recency and geographical origins of both SARS-CoVs that spilled to humans in the past few decades, now in @cp-cell.bsky.social www.cell.com/cell/fulltex...