twistbioscience.com
Synthetic DNA for Health & Sustainability
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Check out our new app note: How the Baker Lab used Multiplexed Gene Fragments and AI guided design to discover novel antibody binders:
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Combatting Global Warming With A $4.3 Million Heifer:
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Taking Control In H5N1 Bird Flu Research With Synthetic DNA:
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Designing Enzymes for the Infinite Recycling and Upcycling of Plastic:
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“Escherichia coli with a 57-codon genetic code” completed with 10kb of Twist genes:
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🙌
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We are excited to see all the projects this year! 🧬
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🗣️ Talk: “Unlocking New Avenues in Antibody Discovery: Integrating Innovative Tools with Hybrid in vivo, in vitro, and in silico Technologies”
🔬 Poster: “Discovery and Optimization of Novel Complement Component 5a Receptor 1 Antagonistic Antibodies”
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Congratulations to all the authors!
@twistbioscience.com
Read the paper here👇
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This is unlike the competitor molecule involved in both pathways that may lead to side effects. Twist antibody leads also show greater inhibition of tumor growth compared to the competitor molecule in the in vivo studies.
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3️⃣ What do you think is the most exciting part of the paper?
Twist antibody leads specifically regulate the Wnt canonical or non-canonical pathway…
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2️⃣ How did Twist products/services contribute to the paper?
Using Twist’s precision DNA writing technologies, we created phage display libraries with a diversity greater than 1 × 10^10 individual members, and machine learning models were utilized for optimal discovery.
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1️⃣ What does the paper accomplish?
We discover antibodies targeting cysteine-rich domain 1 of human DKK1 regulates Wnt non-canonical pathway and activates immune response. Our leads are potent in inhibition of tumor growth and may have promising efficacy for cancer immunotherapy.
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Congratulations to you and your team on the publication!! 🥳 🧬
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Thank you to @twistbioscience.com for sponsoring Rachael’s talk!
#BICC2025
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Learn more in our recent app note— “NGS Liquid Biopsy Solution for Highly Sensitive MRD Detection.”
👉 www.twistbioscience.com/resources/ap...
@twistbioscience.com
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🎉 Congratulations to all the authors on their publications and thank you for choosing @twistbioscience.com to support your work!
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🧬 From Twister and author Michael Bocek— Activation of bacterial programmed cell death by phage inhibitors of host immunity:
www.cell.com/molecular-ce...