A new review paper from Polybio on Targeting the SARS-CoV-2 reservoir in long COVID www.thelancet.com/journals/lan... - ThreadSky

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mildtin.bsky.social • 20 days ago

A new review paper from Polybio on Targeting the SARS-CoV-2 reservoir in long COVID

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00769-2/fulltext

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mildtin.bsky.social•20 days ago

Table 1: Potential reservoir trial therapeutics and mechanisms of action

mildtin.bsky.social•20 days ago

The paper also outlines potential methods for identification and characterisation of the SARS-CoV-2 reservoir, including Quantitative PCR, Metagenomic next-generation sequencing, and Imaging with novel PET
radiotracers

mildtin.bsky.social•20 days ago

There are multiple considerations for targeting the reservoir - the variants that people are infected with (potentially multiple), the duration of therapy needed, which tissues the reservoir might lie in, etc

mildtin.bsky.social•20 days ago

"It is also possible that eradication will not be achievable.
If some cells in which [the reservoir] persists
are long-lived, then maintaining durable suppression,
akin to antiretroviral therapy for HIV infection, might be
a more appropriate approach"

mildtin.bsky.social•20 days ago

A comparison to HIV drug development: "A similar situation existed for HIV in the late 1980s
and early 1990s. Efforts to de-risk the drug development
space via a combination of government and private
funding made multiple industry stakeholders more
willing to engage"

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