A genome-wide CRISPR screen for regulators of astrocyte inflammation identified CLEC16A, linked to MS susceptibility, as a suppressor of NF-κB signaling; CLEC16A promotes mitophagy, and ablating it in astrocytes worsens pathology in an MS model 🧪🧠 www.nature.com/articles/s41... - ThreadSky

natneuro.nature.com • 67 days ago

A genome-wide CRISPR screen for regulators of astrocyte inflammation identified CLEC16A, linked to MS susceptibility, as a suppressor of NF-κB signaling; CLEC16A promotes mitophagy, and ablating it in astrocytes worsens pathology in an MS model 🧪🧠

https://www.nature.com/articles/s41593-025-01875-9

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