Repeat Expansion Disorders. Fascinating stuff.
Reposted from Jeff Carroll, PhD
Very excited to see this study out in the world. We made what is (we think?) the first fully-humanized mouse model of a repeat expansion disorder, DRPLA, by replacing an entire copy of muring Atn1 with human ATN1 with 112 pure CAG repeats...
www.biorxiv.org/content/10.1...

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