🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!! www.nature.com/articles/s41... - ThreadSky

halloulab.bsky.social • 5 days ago

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
https://www.nature.com/articles/s41592-025-02618-1

Comments

mads100tist.bsky.social•4 days ago

Congratulations!

halloulab.bsky.social•4 days ago

Thank you @mads100tist.bsky.social 😀!!

aramariaceleste.bsky.social•5 days ago

Cool!!! Congratulations! 🙌

halloulab.bsky.social•5 days ago

Thank you Mary @aramariaceleste.bsky.social 😊! I hope we will have a chance to catch up soon!

simoesfilipa.bsky.social•3 days ago

Massive congratulations, Adrien - so great to see this out!

halloulab.bsky.social•3 days ago

Thank you Filipa 😊 @simoesfilipa.bsky.social ! Looking forward to catching up with you soon !

annbajur.bsky.social•4 days ago

This is super cool 😎

halloulab.bsky.social•3 days ago

Thank you Anna @annbajur.bsky.social 😀!!

ajclarke.bsky.social•5 days ago

Great work Adrien - congratulations!

halloulab.bsky.social•5 days ago

Thank you Alex @ajclarke.bsky.social 😀 !

bertaverd.bsky.social•4 days ago

Yo! Well done team! @bimidu.bsky.social

halloulab.bsky.social•4 days ago

Thank you Berta @bertaverd.bsky.social 😊! Looking forward to catching up with you later this week! It will be an opportunity to celebrate 🥂😉!

halloulab.bsky.social•5 days ago

Since I started my PhD in 2013, I have been tantalised by a question: can we measure or evaluate the transcriptional and mechanical states of cells in a tissue at the same time? I pursued this question as a postdoc and then as a PI! A🧵on the answer we have found 👇:

halloulab.bsky.social•5 days ago

Using image-based spatial transcriptomics (seqFISH, CosMX, Xenium, etc.) and cell shape-based mechanical force inference, spatial mechano-transcriptomics allows simultaneous spatial profiling of gene expression and mechanical forces at single cell resolution.

halloulab.bsky.social•5 days ago

Using this approach, we were able to study the formation and maintenance of tissue compartment boundaries in the E8.5 mouse embryo:

halloulab.bsky.social•5 days ago

We observed that individual tissue compartments do not have a unique mechanical profile, but that an increased mechanical tension is always observed at the boundary between two different cell types:

halloulab.bsky.social•5 days ago

Using spatial gene expression profiles, we were able to unravel the molecular basis of this biophysical phenotype. Ephrin ligand-receptor interactions control mechanical tension via cell-cell adhesion and cell contractility for cells at tissue compartment boundaries!

halloulab.bsky.social•5 days ago

But spatial mechano-transcriptomics also allowed us to ask a more general question: what is the relationship between the gene expression profile of a cell in a tissue and its mechanical state? This led to the discovery of 'mechano-associated' genes:

martialmillet.bsky.social•5 days ago

Amazing work ! Great for the mechanobiology field 👏

halloulab.bsky.social•4 days ago

Thank you Martial @martialmillet.bsky.social ! We hope that the method will be helpful for other researchers, allowing them to pinpoint the "mechano-associated" genes in their system of interest and will generally help to unravel what we call the "mechanome"...

carmeloferrai.bsky.social•4 days ago

👏🏽

halloulab.bsky.social•4 days ago

Thank you @carmeloferrai.bsky.social 😊!

cytosurge.bsky.social•4 days ago

@carmeloferrai.bsky.social - WOW. Check this out 😀

mehmetcanucar.bsky.social•5 days ago

congrats Adrien this looks super cool! 😍

halloulab.bsky.social•5 days ago

Thank you @mehmetcanucar.bsky.social ! Looking forward to catching up with you soon 😀!

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