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ajclarke.bsky.social
Immunologist. Kennedy Institute of Rheumatology, University of Oxford. https://www.kennedy.ox.ac.uk/research/research-groups/translational-immunometabolism
7 posts 87 followers 92 following
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Posts 19 Comments 7

🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!! www.nature.com/articles/s41...

submitted 7 days ago • 11 comments

Interested in germinal center regulation? Should we coddle our immune system? Two more weeks to apply! 3 year funding

submitted 10 days ago • 0 comments

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

submitted 16 days ago • 7 comments

Rupert Beale @bealelab.bsky.social and co-workers @crick.ac.uk @imperialcollegeldn.bsky.social show that #caspase cleavage of #influenza A #virus M2 disrupts M2-LC3 interaction and regulates virion production. -> www.embopress.org/doi/full/10....

submitted 21 days ago • 0 comments

🚨 We have TWO exciting open positions in our lab! 🚨 We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as: 🔬 Research Assistant www.kennedy.ox.ac.uk/jobs/researc... 💻 Bioinformatics Postdoc www.kennedy.ox.ac.uk/jobs/bioinfo... 📢 Please share!

submitted 28 days ago • 1 comment

Perivascular RELM-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis https://www.biorxiv.org/content/10.1101/2025.02.11.637672v1

submitted 36 days ago • 0 comments

Call your congressional representatives and senators! Save AMERICAN SCIENCE!

submitted 43 days ago • 0 comments

Are you interested in a postdoc with our group studying cancer immunometabolism? If you’re at #KSTcells25 @keystonesymposia.bsky.social DM me and let’s chat!

submitted 47 days ago • 0 comments

The US is withdrawing from the Paris agreement and from the WHO, responsible for the eradication small pox, near eradication of polio and the Ebola vaccine amongst many other. This is a dark day for humanity. Sadly, it will be our children and the next generations that will suffer the consequences.

submitted 62 days ago • 0 comments

New paper alert 📢! (Cell) @cp-cell.bsky.social - How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8

submitted 62 days ago • 3 comments

‼️‼️ Last few days to apply to join us as a #PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden More info on how to apply below (please RT)

submitted 80 days ago • 0 comments

This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social

submitted 100 days ago • 2 comments

Thrilled to share our latest work on how the non-essential amino acid #asparagine metabolically regulates germinal centers. Huge thanks to my PhD supervisor @ajclarke.bsky.social, colleagues, and collaborators at the @ndorms.bsky.social @ox.ac.uk and @crick.ac.uk www.science.org/doi/10.1126/...

submitted 100 days ago • 1 comment

Are you a #WetLab life scientist looking to gain new #DataAnalysis and #omics skills? 🤩 Sign up for our top-rated #bioinformatics #training course 'Omic data analysis and visualisation using R' Starting next week (9 Dec)! Book your place now 👉 bit.ly/4gXvxOF

submitted 111 days ago • 0 comments

✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑‍🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR

submitted 115 days ago • 3 comments

There’s a really exciting range of PhD projects on offer through the MRC “AIM” doctoral training partnership between the Universities of Birmingham, Leicester and Nottingham. 4-year funded studentships with great training opportunities too. Check out the options: more.bham.ac.uk/mrc-aim/phd-...

submitted 116 days ago • 2 comments

Our top-rated #bioinformatics #training course 'Omic data analysis and visualisation using R' starts in less than 2 weeks (9 Dec) Perfect for those who want to gain new #DataAnalysis and #omics skills 🤩 Don't miss out! Book your place now 👉 bit.ly/4gXvxOF

submitted 118 days ago • 0 comments

Glutaminolysis promotes the function of follicular helper T cells in lupus-prone mice https://www.biorxiv.org/content/10.1101/2024.11.25.625088v1

submitted 118 days ago • 0 comments

Join our #SystemsImmunology Lab (Lund University, Sweden) as a #Postdoctoral Fellow! 🔬 Project: To investigate sex hormone regulation of human immune function using CRISPR, transcriptomics, and immunophenotyping. Fully funded 2-year position (more info attached). 🗓️ Apply by Jan 6, 2025

submitted 119 days ago • 0 comments