Does anyone know if anyone's already written the mendelian randomization (IV with genes) version of this paper? - ThreadSky

jonmellon.bsky.social • 9 days ago

Does anyone know if anyone's already written the mendelian randomization (IV with genes) version of this paper?

Reposted from Jon Mellon

unfortunately, I find that the existing IV literature suggests that it looks closer to this:

Comments

zetaof1.bsky.social•9 days ago

@rmcelreath.bsky.social this kinda sounds like a job for you honestly

jonmellon.bsky.social•9 days ago

it seems pretty obvious to me that the real DAG for those studies is going to look more like this

chanret.bsky.social•9 days ago

lol at "lots of mechanisms"

jonmellon.bsky.social•9 days ago

"every mechanism linking social position to outcomes" is the real gut punch I think

jonmellon.bsky.social•9 days ago

from a half-finished blogpost I started writing a while back (comments welcome) https://docs.google.com/document/d/1juYY882DK4XjIBDLdelHcaVecPmfa7zQGA2u6jnrRpQ/edit?usp=sharing

fbedecarrats.bsky.social•9 days ago

I think that it would be very useful. I think that this is related: https://bsky.app/profile/sashagusevposts.bsky.social/post/3lg7224gfi225

jonmellon.bsky.social•9 days ago

Thanks, this is what I’ve got written up as a blog so far https://bsky.app/profile/jonmellon.bsky.social/post/3li5mlr3jqc2r

jonmellon.bsky.social•9 days ago

I bring up the population stratification point in there but the bigger one people seem to miss in practice is that genes affect multiple things

fbedecarrats.bsky.social•9 days ago

My understanding this that Gusev's point relates to your first highlight ("Anything that correlates with membership of a social group with a different prevalence (i.e. all social science variables) is a confounding path to the outcome").

fbedecarrats.bsky.social•9 days ago

A side note: you mention a Vox article in the second half of the text and I did not understand what paper were referring to.

jonmellon.bsky.social•8 days ago

Thanks, it’s the first link but I should make that much clearer in the text

fbedecarrats.bsky.social•9 days ago

This is a great post!

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