Excited and grateful that our initial report on temperature-sensitive protein switches is now published @naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social www.nature.com/articles/s41... Brief thread: - ThreadSky

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bugajlab.bsky.social • 33 days ago

Excited and grateful that our initial report on temperature-sensitive protein switches is now published
@naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social

https://www.nature.com/articles/s41592-024-02572-4

Brief thread:

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evanweberphd.bsky.social•33 days ago

Super cool, congrats Lukasz!

bugajlab.bsky.social•33 days ago

Melt is a single protein that both clusters and translocates to the plasma membrane as a function of temperature.

bugajlab.bsky.social•33 days ago

Melt is highly modular and can endow thermal control over signaling, proteolysis, cell shape, and cell death, among other behaviors, through simple end-to-end fusions. Below, Melt-based induction of cell death in cancer cell lines after cooling by ~10C.

bugajlab.bsky.social•33 days ago

A major promise of thermal control is the ability for precise, non-invasive communication with cells in vivo. Here, Melt allowed temperature-controlled killing of cancer cells in a mouse, in response to local cooling of the mouse's skin (think ice pack).

bugajlab.bsky.social•33 days ago

Many exciting possibilities for Melt and thermal control. Reach out if you'd like to try this in your favorite system!

bugajlab.bsky.social•33 days ago

Big congratulations to the phenomenal scientists that made this happen: Will Benman and Dennis Huang
@dennishuang.bsky.social, along with assists from many others in lab. Perpetually grateful to work with with such exceptional people. 🙏

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