Maybe that would be enough. I wasn't thinking of perma-listing for the interactions, more like creating a timeout. The idea would be to make his account a total pariah, like you have a choice to interact with him or everyone subscribed to the block, but not both.
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I could see that being a useful tactic for more than just Jesse and his ilk - as a wider moderation method in general for discouraging bad behaviour.
Might be an idea for a labeller. 🤔