That sounds more like there's weirdness with whatever is encoding video. The mouse should never become unresponsive, even if RAM is completely filled and the pagefile is being used.
If only Firefox wasn't so dogshit for a bunch of pages I frequently use and especially YouTube. I moved to Brave a while ago which is more performative than anything else.
What blockers are you running? My youtube runs like butter on firefox, I completely forgot it even had ads until a friend showed me something on their computer.
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