How oncogenic clones can eliminate their neighbours to take over space ? There are different ways combining growth and interfacial tension induced compaction. Check out our latest preprint led by Léo Valon and Alexis Matamoro-Vidal to learn more about this 👇 www.biorxiv.org/content/10.1... - ThreadSky

levayerr.bsky.social • 44 days ago

How oncogenic clones can eliminate their neighbours to take over space ? There are different ways combining growth and interfacial tension induced compaction. Check out our latest preprint led by Léo Valon and Alexis Matamoro-Vidal to learn more about this 👇

https://www.biorxiv.org/content/10.1101/2025.01.09.632135v1

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levayerr.bsky.social•44 days ago

We previously showed that Ras activation in clones could eliminate cells by triggering compaction through growth. Checking more in details, we found striking sorting behaviour that also seemed to contribute to cell deformation (Ras cells in purple, WT in the middle)

levayerr.bsky.social•44 days ago

Accordingly, tension at clone interface is higher and WT cells are more compacted near concave boundary and are 2.5X more likely to die in these pockets, in good agreement with the Laplace low which predict more pressure near interface with high curvature.

levayerr.bsky.social•44 days ago

We therefore checked whether increased interfacial tension could indeed generate significant compaction and tried to delineate distinctive features from compaction triggered by differential growth.

levayerr.bsky.social•44 days ago

Using 2D vertex model, we first found that as expected increased interfacial tension was sufficient to round up clones, and generate significant compaction near curved interfaces and cells elongated orthogonal to the clone long axis (movie below shows colour coded compaction for increasing tension)

levayerr.bsky.social•44 days ago

This is quite different in the context of growth-induced compaction where the patches is more isotropically compacted, and cells more elongated parallel to clone long axis (movie below showing compaction for different increase of red cell area).

levayerr.bsky.social•44 days ago

If you now add cell death for a certain area strain threshold, this led to elimination near curved areas in the context of interfacial tension, while more homogenous death distribution in the context of growth (white cells, for different death strain threshold).

halloulab.bsky.social•43 days ago

Many congratulations Romain @levayerr.bsky.social, Léo and Alexis for an insighthful and very elegant study👏 😀!! It highlights once more the key role of higher heterotypic tension in cell sorting, tissue compartmentalisation and clonal dynamics !

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