Hello Bluesky! The PRIMED Consortium is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations. Read more in our recently published Perspective 🧵 1/ www.cell.com/ajhg/fulltex... - ThreadSky

prsdiversity.bsky.social • 116 days ago

Hello Bluesky! The PRIMED Consortium is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations. Read more in our recently published Perspective 🧵 1/ https://www.cell.com/ajhg/fulltext/S0002-9297(24)00379-3

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prsdiversity.bsky.social•116 days ago

This marker paper gives an overview of Consortium objectives and design, ongoing activities, and initial products including new PRS methods, a Consortium data model to enable data harmonization, recommendations on population descriptors, and analytic workflows 2/

prsdiversity.bsky.social•116 days ago

PRS that combine information from multiple diverse populations improve individual risk prediction. PRIMED is developing methods that reflect the full complexity of genetic ancestry, both genome-wide and at specific variants, rather than requiring a single ancestry label for each person 3/

prsdiversity.bsky.social•116 days ago

PRIMED has built off of the @nationalacademies.org recommendations on population descriptors in genomics research to develop a practical implementation of a data model for collecting and working with population descriptor data 4/
https://nap.nationalacademies.org/catalog/26902/using-population-descriptors-in-genetics-and-genomics-research-a-new

prsdiversity.bsky.social•116 days ago

Genetic risk is only one factor in a person’s overall disease risk. PRIMED is also investigating how to include non-genetic factors such as environmental exposures (e.g. pollution) and social determinants of health (e.g. food access, discrimination) into overall risk models. 5/

prsdiversity.bsky.social•116 days ago

PRIMED is one of the first consortia to use the NHGRI AnVIL cloud platform as a collaborative hub for research. Policy and technical solutions to enable secure data sharing and analysis in the cloud are presented. Analysis tools and workflows and a data model are publicly available. 6/

prsdiversity.bsky.social•116 days ago

PRIMED is also building collaborations across diverse global datasets and investigators to continue working towards equity of genomic prediction across the globe - follow us here and find out more at primedconsortium@uw.edu. PRIMED is funded by NHGRI and NCI /end

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