This marker paper gives an overview of Consortium objectives and design, ongoing activities, and initial products including new PRS methods, a Consortium data model to enable data harmonization, recommendations on population descriptors, and analytic workflows 2/ - ThreadSky

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prsdiversity.bsky.social • 115 days ago

This marker paper gives an overview of Consortium objectives and design, ongoing activities, and initial products including new PRS methods, a Consortium data model to enable data harmonization, recommendations on population descriptors, and analytic workflows 2/

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prsdiversity.bsky.social•115 days ago

PRS that combine information from multiple diverse populations improve individual risk prediction. PRIMED is developing methods that reflect the full complexity of genetic ancestry, both genome-wide and at specific variants, rather than requiring a single ancestry label for each person 3/

prsdiversity.bsky.social•115 days ago

PRIMED has built off of the @nationalacademies.org recommendations on population descriptors in genomics research to develop a practical implementation of a data model for collecting and working with population descriptor data 4/
https://nap.nationalacademies.org/catalog/26902/using-population-descriptors-in-genetics-and-genomics-research-a-new

prsdiversity.bsky.social•115 days ago

Genetic risk is only one factor in a person’s overall disease risk. PRIMED is also investigating how to include non-genetic factors such as environmental exposures (e.g. pollution) and social determinants of health (e.g. food access, discrimination) into overall risk models. 5/

prsdiversity.bsky.social•115 days ago

PRIMED is one of the first consortia to use the NHGRI AnVIL cloud platform as a collaborative hub for research. Policy and technical solutions to enable secure data sharing and analysis in the cloud are presented. Analysis tools and workflows and a data model are publicly available. 6/

prsdiversity.bsky.social•115 days ago

PRIMED is also building collaborations across diverse global datasets and investigators to continue working towards equity of genomic prediction across the globe - follow us here and find out more at [email protected]. PRIMED is funded by NHGRI and NCI /end

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