These tirzepatide miracles are almost becoming routine Weight down 110 lbs Hgb a1c from 12 to 8 Cr from 3.4 to 2.8 Albumin Cr ratio from 1254 to 280 All at 5 mg a week - ThreadSky

kidneyboy.bsky.social • 19 days ago

These tirzepatide miracles are almost becoming routine
Weight down 110 lbs
Hgb a1c from 12 to 8
Cr from 3.4 to 2.8
Albumin Cr ratio from 1254 to 280

All at 5 mg a week

Comments

carkur.bsky.social•18 days ago

I hope one day they become more affordable in the US or more covered by insurance. Even the compounds are wildly expensive. Alas.

kidneyboy.bsky.social•18 days ago

They will, they always do. One pill, once-a-day, antiretroviral therapy is a buck a day now. We will see similar price drops for GLP1ra

rnflex.bsky.social•19 days ago

Does things we thought were impossible just a generation ago and the best is yet to come which is even wilder.

stevenmathern.bsky.social•18 days ago

that is an impressive accomplishment with only 5mg/week

kidneyboy.bsky.social•18 days ago

I don't have a ton of experience with tirzepatide, but looking at SURMOUNT-1, there isn't that much dose respoinse. You get a lot with 5 mg.

https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

stevenmathern.bsky.social•18 days ago

when u take 5mg every 5days... after about 5wks... the 'dose response' is better than 5mg every 7days imo

drmag00.bsky.social•18 days ago

I’m starting it today. Fingers crossed.

kidneyboy.bsky.social•18 days ago

I hope you do great.

drmag00.bsky.social•18 days ago

Thank you. 😁

brianwernham.bsky.social•18 days ago

How are you feeling?

drmag00.bsky.social•18 days ago

I haven’t noticed any changes, honestly. I suppose that’s good. I’ll see, I guess, as the week goes and I get to my second dose.

gleeming53.bsky.social•18 days ago

Do you find that you are very nauseous on it?

kidneyboy.bsky.social•18 days ago

Some people report this, especially when they first start the drugs (or go up to a new dose) and some patients are unable to tolerate it but not too many.

gleeming53.bsky.social•17 days ago

It’s good to hear that it’s a smaller percentage of those who cannot tolerate the effects. Thanks.

brianwernham.bsky.social•18 days ago

It's my first day 2.5mg
120 Kg BMI 38
8 hours in
Slightly nauseous
I'm in the kitchen but not snacking. Placebo effect?

Looking at the scientific research 5mg a week seems to give almost as much result as 10mg

I'm a bit worried about hair loss though, so maybe I want to stay at 5 mg and see?

mikejohansenmd.medsky.social•16 days ago

The studies kinda tell the truth about the effect. It is quite variable. Some people just need a little, others need way more, others get too many side effects, and some don't get much benefit. Predicting who will be in what group is trial and error.

brianwernham.bsky.social•16 days ago

2 days in, down 0.6kg

gleeming53.bsky.social•15 days ago

That’s fantastic! Keep it up!

gleeming53.bsky.social•17 days ago

That’s good information. My husband had very good effects losing weight, but he’s also very stoic when he’s uncomfortable. Hard to tell what would be typical.

ratman1967.bsky.social•18 days ago

That's awesome! Now watch ##ActingPresidentMusk raise the prices 500%.

brianwernham.bsky.social•18 days ago

It's available for free on the National Health Service in the UK. It was authorised in December.

aineyoremd.bsky.social•19 days ago

These drugs are, not exaggerating, transformative in the same way HAART was for HIV, and the Salk vaccine for polio, and for a *much* larger swathe of the population.

rnflex.bsky.social•19 days ago

I'd even argue the dual agonists and especially the triagonists in development are on the level of penicillin and tetracyclines. Literally changing the actual foundations of medicine.

kidneyboy.bsky.social•19 days ago

HAART will always stand alone in my mind because the difference was so dramatic and fast. We had people that were dying in front of your eyes and healed in months.

I graduated med school in 1995, 25% of the inpatients in Detroit were HIV complications

aineyoremd.bsky.social•19 days ago

Yeah same I remember the HIV ward in the hospital in the gay area of Chicago just … emptied out.

Sadly I went to Baltimore for residency where the large IVDU population had limited access to the meds so we saw all the bad stuff. (Also finished in 2000)

kidneyboy.bsky.social•19 days ago

Yeah, going from Detroit to Indiana might have had something to do with my experience 🤔

kidneyboy.bsky.social•19 days ago

By the time I finished residency in 2000 (yeah, yeah, I know, I took my time going through residency), HIV was largely a curiosity on the PMH, rather than reason for admission

thetirednurse.bsky.social•18 days ago

I have had patients go from A1c of 15 to less than 7! Some have been on large doses of U500, now just taking mounjaro 5-7.5 mg. They also feel great and are so happy. It’s amazing.

rolfk.bsky.social•19 days ago

These numbers are worth some side effects! A BMI 27-ish patient who is pretty active asked me about effect on lean muscle mass. I know the book reply: some though a fraction of total weight loss... are you hearing any reports of reduction in strength or endurance in active patients?

kidneyboy.bsky.social•19 days ago

I have not. Just the opposite in fact, patients are reporting that the weight loss is allowing them to have more activity.

dylanmackayphd.bsky.social•19 days ago

It is a hell of a drug as they say

mdwallach.bsky.social•18 days ago

It’s so good

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