#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social - ThreadSky

dfachinetti.bsky.social • 49 days ago

#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
https://www.nature.com/articles/s41556-024-01565-x. Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social

Comments

ksiudeja.bsky.social•49 days ago

Cool stuff! Congratulations to all!

erhardtlab.bsky.social•49 days ago

Congratulations Dani and Solene! Looking forward to reading the final story!

dfachinetti.bsky.social•49 days ago

#2 Using a genetic system to induce controlled errors during mitosis we demonstrate that chromosome segregation errors alter nuclear shape and its mechanical properties. These abnormalities rapidly trigger the p53 checkpoint, preventing aneuploid cells from proliferating.

dfachinetti.bsky.social•49 days ago

#3 We further identified the molecular mechanisms that sense these nuclear mechanical and shape abnormalities by showing that these changes are sensed by the mTORC2 complex and the ATR protein which subsequently activate p53.

dfachinetti.bsky.social•49 days ago

#4 We also found that this surveillance mechanism is activated in aging-related setting, such as in a disease condition called progeria, which is characterized by altered assembly of the nuclear lamina at the cellular level

dfachinetti.bsky.social•49 days ago

#5 While the sensing of nuclear mechanical alterations limits the proliferation of abnormal cells, we find that the increased in nuclear flexibility enhances the ability of aneuploid cells to deform and invade complex environments, a process that may promote metastasis in p53 deficient context

dfachinetti.bsky.social•49 days ago

#6 This work supported by @institutcurie.bsky.social @cnrs.bsky.social NIH @agencerecherche.bsky.social underscores a novel role of nuclear shape & mechanics in preserving genome stability, offering a promising pathway for improved detection of pathological cells in cancer and aging-related diseases