important thread 👇

{norepi + vaso} can often induce a state of *normotensive* vasoconstrictive shock

this is why I dislike blind algorithms that start with NE, then pile on vaso on without considering global hemodynamics

for experts, there is no such thing as a “1st/2nd/3rd line” pressor #EMIMCC
If the LV of the patient with sepsis is «hyperdynamic» when on noradrenaline, then EF dropps and the LV looks poorly when vasopressin is added, but recovers to normal with dobutamine, you likely haven’t «uncovered hidden LV dysfunction» or septic cardiomyopathy. #emimcc #pocus #echofirst 1/

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