Very good study led by @chapelmadison.bsky.social on genetic variant effects, reminding us that complex things are indeed complex. Good examples showing the impact of polygenic background. Thread + link to preprint 👇
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Madison Chapel
1/ Interested in how genetic variants influence complex traits? In our new preprint, we show that variant effects depend on the polygenic background in which they occur, and why it is critical to consider polygenic background when studying complex traits. www.biorxiv.org/content/10.1...
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