(1/5)Delighted to share our new study in @cp-cellrepphyssci.bsky.social @cellpress.bsky.social, a glimpse of how intelligent systems can accelerate biology when data are scarce. - ThreadSky

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delafuentelab.bsky.social • 28 days ago

(1/5)Delighted to share our new study in
@cp-cellrepphyssci.bsky.social @cellpress.bsky.social, a glimpse of how intelligent systems can accelerate biology when data are scarce.

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delafuentelab.bsky.social•28 days ago

(2/5)With only 36 training molecules, our model proposed 8 inhibitors against enterovirus 71. Bench assays confirmed 5, which is ~10× the hit-rate of classical screens, compressing months of iteration into days.

delafuentelab.bsky.social•28 days ago

(3/5)EV71, the main cause of hand-foot-mouth disease, can lead to severe neurological complications and still lacks an approved therapy. By binding conserved viral pockets, these compounds suggest routes to both potent inhibition and reduced escape.

delafuentelab.bsky.social•28 days ago

(4/5) This work is a testament to what’s possible when deep learning and experiment move in lock-step. Thanks to the collaboration between #ProcterGamble, @cornelluniversity.bsky.social

delafuentelab.bsky.social•28 days ago

(5/5)And a brilliant team: Angela Cesaro, Fangping Wan, Haoyuan Shi, Kaiyang Wang, C. Mark Maupin, Matt L. Barker, Jiqian Liu, Stephen J. Fox, @jingjieyeo.bsky.social .

Link to paper: https://www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(25)00153-5

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