I think epic-editing is the way to go for many diseases - I know the genome editing folks love slicing and dicing DNA, but I get really nervous about unintended consequences. Especially in the brain where you can't just regenerate f'd up cells.
Reposted from Eric Topol
Most genome editing work to date has been DNA based. A new paper out today assessed a single dose of epigenetic editing (thru PCSK9) for marked (~70%) and durable reduction of LDL cholesterol [in non-human primates]
www.nature.com/articles/s41...

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