The DNA Topology Lab of IBMB developed Topo-seq to measure how DNA is deformed along the genome. Nucleosomal DNA has topological memory.
Segura J, Díaz-Ingelmo O, Martínez-García B, Ayats-Fraile A, Nikolaou C, Roca J.
Nature Commun. 2024 doi: 10.1038/s41467-024-49023-4.