I know this is an old post, but it's the Magnum in Resident Evil 0-3 (especially RE2).
It's so good and powerful that you're scared to use it on a non-boss enemy, but by the time you beat the boss you realize you still have most of the ammo you saved up.
The pipe shotgun in Tormented Souls just looks so good and it feels like a game changer from the nail gun. Also Isaacs boot in Dead Space has the most satisfying stomp in video games.
Love a good bow and arrow, where you can rip out your arrows again from the fallen enemies. So Last of Us... oooor maybe the crossbow from Evil Within. The hits are super satisfying and it's very versatile with it's different ammo types.
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It's so good and powerful that you're scared to use it on a non-boss enemy, but by the time you beat the boss you realize you still have most of the ammo you saved up.
The comfort it gives💆