A selection of papers in 2024 associated with developmental timing & mammalian pausing.
🐭⌛️👤⏳
#EvoDevoTempo
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🐭⌛️👤⏳
#EvoDevoTempo
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Comments
@studerl.bsky.social
An epigenetic modulators affect timing of human neuronal maturation. Transient inhibition of EZH2, EHMT1 and EHMT2 or DOT1L, at progenitor stage primes newly born neurons to rapidly acquire mature properties upon differentiation.
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@aliseleit.bsky.social
Aulehla lab
Quantitative analysis using developmental quantitative trait loci (devQTL) mapping
in 🐠 embryos shows decoupling of timing from size control, while spatial scaling is preserved.
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@ebisuyamiki.bsky.social
Selective effects of metabolic activities on segmentation clock processes, suggesting that scaling of biochemical properties may be achieved through combinations of multiple modulators.
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@ebisuyamiki.bsky.social
Pervasive slower protein degradation in human vs mouse. Changes in glycolysis affect protein turnover.
*we posted an in-depth analysis of differences in protein turnover in mouse and human neural progenitors and their role on tempo as well
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& conserved mechanisms of dormancy in human embryos @bulutkarslioglu.bsky.social
https://www.sciencedirect.com/science/article/pii/S1934590924002509
https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(24)00977-2
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@kkukreja.bsky.social
Allon Klein lab
Cell cycle arrest slows down differentiation of some cell types and induces global stress responses in 🐠. Cells can differentiate without cell division, yet proportions of cells are affected.
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