⚪️ Why are 3D models revolutionizing obesity research? Because adipose tissue is more than fat; it’s a dynamic, mechano-sensing organ, and thus a hub of metabolic disease. 🧵 1/5 - ThreadSky

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adlunglab.com • 23 days ago

⚪️ Why are 3D models revolutionizing obesity research? Because adipose tissue is more than fat; it’s a dynamic, mechano-sensing organ, and thus a hub of metabolic disease. 🧵

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adlunglab.com•23 days ago

🧫 Traditional 2D cell cultures and animal models fall short. They miss the complex cell–extracellular matrix (ECM) interactions, tissue inflammation, and fibrosis seen in human obesity.
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adlunglab.com•23 days ago

🧱 Enter scaffold-based 3D models. These models recreate the architecture and mechanical environment of adipose tissue. ECM stiffness, vascular networks, and co-culture with immune cells; all critical to mimicking real-world obesity pathophysiology.

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adlunglab.com•23 days ago

🔬 From insulin-resistant spheroids to perfused chips replicating crown-like immune structures, recent advances offer biomimetic platforms to dissect adipose tissue dysfunction, screen drugs, and even tailor patient-specific therapies.

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adlunglab.com•23 days ago

🧠 This review in @cp-trendsbiotech.bsky.social is a great read for metabolic researchers, tissue engineers, and translational scientists. Kudos to Nicola Contessi Negrini and Vanessa Pellegrinelli for this essential synthesis.

🔗 https://doi.org/10.1016/j.tibtech.2024.09.017 🧪

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