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adlunglab.com
Data-driven & knowledge-based. Rooted in Hamburg, Germany. Adipose and/or Systems Biology + Inflammation. Account handled by π @LorenzAdlung.com www.adlunglab.com
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🍽️ Can autophagy increase with age rather than decline? 🤔 What if the story we’ve been told about its decline is missing key details? ⤵️ #aging

submitted 11 days ago • 1 comment

🔎 And another one: Is the body-mass index (BMI) really the best measure of obesity risk in inflammatory bowel disease (IBD)? 🧑🏻‍💻 New data suggest visceral fat tells a more predictive story. 🧵 1/5

submitted 13 days ago • 1 comment

🔥 How are obesity, type 2 diabetes (T2D), and inflammatory bowel diseases (IBD) all connected? 👀 It’s more than coincidence; let's look at the evidence. 🧵 1/5

submitted 13 days ago • 1 comment

Next week, on my birthday, I'll be in beautiful Bremen to deliver a talk at the Bremen Life Sciences Meeting: sites.google.com/view/bremen-... Looking forward to it! 🥳

submitted 17 days ago • 0 comments

🧊 How does the liver contribute to cold tolerance? A new study finds lysosomes to be lipid regulators that help power whole-body physiology through the cold. 🧵 1/5

submitted 17 days ago • 1 comment

💓 Global data from 2M+ people show those free of five classic cardiovascular disease risks at age 50 gain over a decade of life. 🫀🚬 Hypertension and smoking are the most impactful to modify in midlife. 📰 @nejm.org paper from our colleagues at UKE: doi.org/10.1056/NEJM... 🧪

submitted 17 days ago • 0 comments

🧓💥 Why does intestinal inflammation linger longer with age? 📰 A new @cp-cellhostmicrobe.bsky.social paper gives the answer! 👇🏻

submitted 18 days ago • 1 comment

💉 Vaccines for future variants? This @cp-immunity.bsky.social paper unveils "EVE-Vax", a computational design tool that predicts antibody-evading mutations before they emerge. 83 designed spike proteins mimicked real-world evolution up to two years in advance! doi.org/10.1016/j.im... 🧪

submitted 19 days ago • 0 comments

submitted 19 days ago • 0 comments

🧩 Ever wish you could watch molecules reveal their shape & size? Entropic traps make it possible. The brother of one of our lab members just published a really cool technology in @Science.org: “Escape-time stereometry” (ETs), a fast, ultra-sensitive technique for molecular conformation. 🧵 1/4

submitted 19 days ago • 1 comment

😱 Ever wondered how fat breakdown might drive anxiety? 📰 A new paper uncovers a strikink link: stress-induced lipolysis → GDF15 secretion → anxiety-like behavior. 🚏 A metabolism–mind connection, decoded! 🧵 1/4

submitted 20 days ago • 1 comment

🤩 Wonderful work from my good friend ‪@larsplus.bsky.social‬ on fundamental governing principles of gene expression out now in Cell. Congratulations, Lars, and: Happy Birthday! 🥳 🧵 1/4

submitted 23 days ago • 2 comments

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵

submitted 24 days ago • 4 comments

⚪️ Why are 3D models revolutionizing obesity research? Because adipose tissue is more than fat; it’s a dynamic, mechano-sensing organ, and thus a hub of metabolic disease. 🧵 1/5

submitted 24 days ago • 1 comment

The Krebs cycle isn’t just about metabolism, it shapes myeloid function! A @cp-cellmetabolism.bsky.social review by @lukeanthonyoneill.bsky.social highlights how itaconate, succinate & fumarate rewire macrophages, offering new therapeutic angles, e.g. in inflammation. doi.org/10.1016/j.cm... 🧪

submitted 25 days ago • 0 comments

Global gut microbiome diversity just got a high-res map! Massive strain-level analysis of 32K samples links microbial phylogeny to geography and health, highlighting clades tied to cancer and aging. Led by @seandreu.bsky.social from @cibiocm.bsky.social 🧪 doi.org/10.1016/j.ce...

submitted 25 days ago • 0 comments

m6A marks mRNAs for decay—but this paper reveals the twist: tRNA mods like mcm5s2U can rescue them by improving codon decoding. A pan-epitranscriptomic balancing act with major implications for cancer biology. Brilliant work from @mcm5s2u.bsky.social & Lars Steinmetz 🧪 doi.org/10.1016/j.ce...

submitted 26 days ago • 0 comments

A huge leap for single-cell proteomics: SC-pSILAC reveals protein turnover alongside abundance in >1,000 cells, unlocking new insights into differentiation, drug response, and cell-cycle dynamics. Amazing work from @jespervolsen.bsky.social 🧪 doi.org/10.1016/j.ce...

submitted 26 days ago • 0 comments

👀 Macrophages matter for more than just immunity! This preprint from @sabanlab.bsky.social reveals resident tissue macrophages control eye pressure by regulating extracellular matrix in the trabecular meshwork. Just discussed in @natrevimmunol.nature.com. 🧪 doi.org/10.1101/2025...

submitted 27 days ago • 1 comment