Stem cell therapies hold great potential for stroke recovery; but when is the optimal time for transplantation? 🧠💉⏲️ Our latest preprint shows that delaying NPC therapy by one week post-stroke increases long-term graft survival 20-fold. www.biorxiv.org/content/10.1... - ThreadSky

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rrust.bsky.social • 91 days ago

Stem cell therapies hold great potential for stroke recovery; but when is the optimal time for transplantation? 🧠💉⏲️

Our latest preprint shows that delaying NPC therapy by one week post-stroke increases long-term graft survival 20-fold.

https://www.biorxiv.org/content/10.1101/2025.02.13.638119v1

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rrust.bsky.social•91 days ago

We found that increased long-term graft survival was mainly due to higher NPC proliferation within days after transplantation. In both groups, most grafts differentiated into neurons or glia, with no pluripotent residuals at 6 weeks after stroke

profbrunt.bsky.social•90 days ago

What was the estimated cell graft input to survival ratio looking like? We have been struggling with 80-90% loss post installation in peripheral organs, any sign of rejection?

Still, we are working to build devices to support cell therapy ($PKTX).

rrust.bsky.social•90 days ago

@profbrunt.bsky.social great Q, a bit difficult to estimate for us because NPC also proliferate few times before maturation. But we estimate that we have a initial survival of 20-40%. We have a bit of experience with preconditioning so we can get probably >50% survival.

profbrunt.bsky.social•90 days ago

That is still pretty good! Thanks for the extra paper.

rrust.bsky.social•90 days ago

@profbrunt.bsky.social Please keep in mind for this study we did local transplantations. Here is an older one looking at systemic injections: https://pubmed.ncbi.nlm.nih.gov/19617198/

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